DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells.
about
Mutator pathways unleashed by epigenetic silencing in human cancerO6-(fluorobenzyl)guanine and chloroethylnitrosourea in xenografted rat brain tumor in vivoInfluence of the Expression Level of O6-Alkylguanine-DNA Alkyltransferase on the Formation of DNA Interstrand Crosslinks Induced by Chloroethylnitrosoureas in Cells: A Quantitation Using High-Performance Liquid Chromatography-Mass SpectrometryIncreasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agentRepair of O6-ethylguanine in DNA protects rat 208F cells from tumorigenic conversion by N-ethyl-N-nitrosoureaElevated DNA topoisomerase II activity in nitrogen mustard-resistant human cells.O(6)-methylguanine-DNA methyltransferase in equine sarcoids: molecular and epigenetic analysis.Development of distamycin-related DNA binding anticancer drugs.Cancer chemotherapy: new strategies for success.Polyglutamation of methotrexate. Is methotrexate a prodrug?Novobiocin enhances alkylating agent cytotoxicity and DNA interstrand crosslinks in a murine model.Gene therapy to protect haematopoietic cells from cytotoxic cancer drugs.Repair of O6-(2-chloroethyl)guanine mediates the biological effects of chloroethylnitrosoureasStudies of the repair of O6-alkylguanine and O4-alkylthymine in DNA by alkyltransferases from mammalian cells and bacteria.Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing.Misonidazole and CCNU: further evidence for a pharmacokinetic mechanism of chemosensitization and therapeutic gain.Patterns of cross-sensitivity in the responses of clonal subpopulations isolated from the RIF-1 mouse sarcoma to selected nitrosoureas and nitrogen mustards.The effects of pretreatment of human tumour cells with MNNG on the DNA crosslinking and cytotoxicity of mitozolomide.Phosphotriester formation by the haloethylnitrosoureas and repair of these lesions by E. coli BS21 extracts.Formation of covalent complexes between human O6-alkylguanine-DNA alkyltransferase and BCNU-treated defined length synthetic oligodeoxynucleotidesThe effect of a chalcogenapyrylium dye with and without photolysis on mitochondrial function in normal and tumor cells.Cellular pharmacology of novel C8-linked anthramycin-based sequence-selective DNA minor groove cross-linking agents.DNA interstrand cross-linking and cytotoxicity induced by chloroethylnitrosoureas and cisplatin in human glioma cell lines which vary in cellular concentration of O6-alkylguanine-DNA alkyltransferase.Protection against chloroethylnitrosourea cytotoxicity by eukaryotic 3-methyladenine DNA glycosylase.Novel human DNA alkyltransferases obtained by random substitution and genetic selection in bacteriaDNA-mediated transfer and expression of a human DNA repair gene that demethylates O6-methylguanine.Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli.Metabolism of the chloroethylnitrosoureas.Alkylating agent resistance: in vitro studies with human cell lines.O6-Alkylguanine-DNA alkyltransferase activity correlates with the therapeutic response of human rhabdomyosarcoma xenografts to 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea.Overexpressed human metallothionein IIA gene protects Chinese hamster ovary cells from killing by alkylating agents.Multifaceted roles of alkyltransferase and related proteins in DNA repair, DNA damage, resistance to chemotherapy, and research tools.Molecular status of pituitary carcinoma and atypical adenoma that contributes the effectiveness of temozolomide.Quantification of DNA interstrand crosslinks induced by ACNU in NIH/3T3 and L1210 cells using high-performance liquid chromatography/electrospray ionization tandem mass spectrometry.DNA polymerase II (polB) is involved in a new DNA repair pathway for DNA interstrand cross-links in Escherichia coliChemoprotection of human hematopoietic stem cells by simultaneous lentiviral overexpression of multidrug resistance 1 and O(6)-methylguanine-DNA methyltransferase(P140K).Potentiation of temozolomide and BCNU cytotoxicity by O(6)-benzylguanine: a comparative study in vitro.Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene.Glutathione, cell proliferation, and 1,3-bis-(2-chloroethyl)-1-nitrosourea in K562 leukemia.Cross-linking of DNA induced by chloroethylnitrosourea is presented by O6-methylguanine-DNA methyltransferase
P2860
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P2860
DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells.
description
1980 nî lūn-bûn
@nan
1980年の論文
@ja
1980年論文
@yue
1980年論文
@zh-hant
1980年論文
@zh-hk
1980年論文
@zh-mo
1980年論文
@zh-tw
1980年论文
@wuu
1980年论文
@zh
1980年论文
@zh-cn
name
DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells.
@en
type
label
DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells.
@en
prefLabel
DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells.
@en
P2093
P356
P1433
P1476
DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells.
@en
P2093
P2888
P304
P356
10.1038/288727A0
P407
P577
1980-12-01T00:00:00Z
P6179
1037190113