Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity.
about
Predicting effective microRNA target sites in mammalian mRNAsSystematic analysis of off-target effects in an RNAi screen reveals microRNAs affecting sensitivity to TRAIL-induced apoptosisDesigning of highly effective complementary and mismatch siRNAs for silencing a genePrimary ciliogenesis requires the distal appendage component Cep123.High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagyThe miR-15/107 group of microRNA genes: evolutionary biology, cellular functions, and roles in human diseasesA novel biochemical method to identify target genes of individual microRNAs: identification of a new Caenorhabditis elegans let-7 targetStatistical methods for analysis of high-throughput RNA interference screensTherapeutic application of RNAi: is mRNA targeting finally ready for prime time?Transcripts targeted by the microRNA-16 family cooperatively regulate cell cycle progressionsiRNA and RNAi optimizationsiRNA Versus miRNA as Therapeutics for Gene SilencingNucleic acid targeting: towards personalized therapy for head and neck cancer.Emerging strategies for RNA interference (RNAi) applications in insectsFighting against kidney diseases with small interfering RNA: opportunities and challengesAbasic pivot substitution harnesses target specificity of RNA interferenceEnhancement of the Seed-Target Recognition Step in RNA Silencing by a PIWI/MID Domain ProteinGenetic screens and functional genomics using CRISPR/Cas9 technologySynthetic RNAs for Gene Regulation: Design Principles and Computational ToolsKnocking down disease: a progress report on siRNA therapeuticsCell-Based Assay Design for High-Content Screening of Drug CandidatesPreclinical and clinical development of siRNA-based therapeuticsCurrent prospects for RNA interference-based therapiesProgress toward in vivo use of siRNAs-IIAn intermittent live cell imaging screen for siRNA enhancers and suppressors of a kinesin-5 inhibitorRNAi-mediated knock-down of arylamine N-acetyltransferase-1 expression induces E-cadherin up-regulation and cell-cell contact growth inhibitionRelationship of axonal voltage-gated sodium channel 1.8 (NaV1.8) mRNA accumulation to sciatic nerve injury-induced painful neuropathy in ratsZscan4: a novel gene expressed exclusively in late 2-cell embryos and embryonic stem cellsNon-human lnc-DC orthologs encode Wdnm1-like proteinsiRNA off-target effects can be reduced at concentrations that match their individual potencyPotential siRNA Molecules for Nucleoprotein and M2/L Overlapping Region of Respiratory Syncytial Virus: In Silico DesignOff-target effects dominate a large-scale RNAi screen for modulators of the TGF-β pathway and reveal microRNA regulation of TGFBR2mRNA turnover rate limits siRNA and microRNA efficacySignatures of RNA binding proteins globally coupled to effective microRNA target sitesTarget mRNA abundance dilutes microRNA and siRNA activityTransfection of small RNAs globally perturbs gene regulation by endogenous microRNAsSilencing disease genes in the laboratory and the clinicRNA Interference and Cancer TherapyGenome-scale CRISPR-Cas9 knockout screening in human cellsLHCBM1 and LHCBM2/7 polypeptides, components of major LHCII complex, have distinct functional roles in photosynthetic antenna system of Chlamydomonas reinhardtii.
P2860
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P2860
Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Widespread siRNA "off-target" ...... gion sequence complementarity.
@en
type
label
Widespread siRNA "off-target" ...... gion sequence complementarity.
@en
prefLabel
Widespread siRNA "off-target" ...... gion sequence complementarity.
@en
P2093
P2860
P356
P1433
P1476
Widespread siRNA "off-target" ...... gion sequence complementarity.
@en
P2093
Aimee L Jackson
B Nelson Chau
Janell Schelter
Julja Burchard
Michele Cleary
Peter S Linsley
P2860
P304
P356
10.1261/RNA.25706
P407
P577
2006-05-08T00:00:00Z