Mitoxantrone resistance in HL-60 leukemia cells: reduced nuclear topoisomerase II catalytic activity and drug-induced DNA cleavage in association with reduced expression of the topoisomerase II beta isoform.
about
Topoisomerase IIalpha binding domains of adenomatous polyposis coli influence cell cycle progression and aneuploidy.Mechanisms regulating resistance to inhibitors of topoisomerase II.G226, a new epipolythiodioxopiperazine derivative, triggers DNA damage and apoptosis in human cancer cells in vitro via ROS generation.DNA topoisomerase II as a target for cancer chemotherapy.Acidic pH induces topoisomerase II-mediated DNA damage.XK469, a selective topoisomerase IIbeta poison.Altered stability of etoposide-induced topoisomerase II-DNA complexes in resistant human leukaemia K562 cellsSynthesis and Biological Evaluation of Novel Phosphatidylcholine Analogues Containing Monoterpene Acids as Potent Antiproliferative AgentsMechanisms of resistance to combinations of vincristine, etoposide and doxorubicin in Chinese hamster ovary cells.Spontaneous overexpression of the long form of the Bcl-X protein in a highly resistant P388 leukaemia.Isoprenoid-phospholipid conjugates as potential therapeutic agents: Synthesis, characterization and antiproliferative studiesA role for topoisomerase II alpha in the formation of radiation-induced chromatid breaksOverexpression of Mcl-1 confers multidrug resistance, whereas topoisomerase IIβ downregulation introduces mitoxantrone-specific drug resistance in acute myeloid leukemiaMitoxantrone, More than Just Another Topoisomerase II Poison.Emodin triggers DNA double-strand breaks by stabilizing topoisomerase II-DNA cleavage complexes and by inhibiting ATP hydrolysis of topoisomerase II.Topoisomerase II is required for mitoxantrone to signal nuclear factor kappa B activation in HL60 cells.Multidrug resistance-associated protein-mediated multidrug resistance modulated by cyclosporin A in a human bladder cancer cell line.Reduced topoisomerase II activity in multidrug-resistant human non-small cell lung cancer cell lines.Characterization of the human topoisomerase IIbeta (TOP2B) promoter activity: essential roles of the nuclear factor-Y (NF-Y)- and specificity protein-1 (Sp1)-binding sites.Proliferation-associated nuclear antigen Ki-S1 is identical with topoisomerase II alpha. Delineation of a carboxy-terminal epitope with peptide antibodies.Relationship between expression of topoisomerase II isoforms and intrinsic sensitivity to topoisomerase II inhibitors in breast cancer cell lines.DNA damage-mediated apoptosis induced by selenium compounds.Design, Synthesis, and Evaluation of ω-(Isothiocyanato)alkylphosphinates and Phosphine Oxides as Antiproliferative Agents.
P2860
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P2860
Mitoxantrone resistance in HL-60 leukemia cells: reduced nuclear topoisomerase II catalytic activity and drug-induced DNA cleavage in association with reduced expression of the topoisomerase II beta isoform.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
Mitoxantrone resistance in HL- ...... topoisomerase II beta isoform.
@en
type
label
Mitoxantrone resistance in HL- ...... topoisomerase II beta isoform.
@en
prefLabel
Mitoxantrone resistance in HL- ...... topoisomerase II beta isoform.
@en
P2093
P356
P1433
P1476
Mitoxantrone resistance in HL- ...... topoisomerase II beta isoform.
@en
P2093
P304
P356
10.1021/BI00105A020
P407
P577
1991-10-01T00:00:00Z