G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment.
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Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest.The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processingNRP/B, a novel nuclear matrix protein, associates with p110(RB) and is involved in neuronal differentiationThe hbrm and BRG-1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosisThe promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma proteinFli-1, an Ets-related transcription factor, regulates erythropoietin-induced erythroid proliferation and differentiation: evidence for direct transcriptional repression of the Rb gene during differentiation.Affinity for the nuclear compartment and expression during cell differentiation implicate phosphorylated Groucho/TLE1 forms of higher molecular mass in nuclear functionsHuman OGG1 undergoes serine phosphorylation and associates with the nuclear matrix and mitotic chromatin in vivoNucleocytoplasmic shuttling of p130/RBL2: novel regulatory mechanism.Lamin A/C binding protein LAP2alpha is required for nuclear anchorage of retinoblastoma proteinThe retinoblastoma protein is phosphorylated on multiple sites by human cdc2Induction of S-phase entry by E2F transcription factors depends on their nuclear localizationHypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRbHuman chromatid cohesin component hRad21 is phosphorylated in M phase and associated with metaphase centromeresPRL-1, a unique nuclear protein tyrosine phosphatase, affects cell growthDual mechanisms of repression of E2F1 activity by the retinoblastoma gene productCytoplasmic localization of human cdc25C during interphase requires an intact 14-3-3 binding sitep53 binds the nuclear matrix in normal cells: binding involves the proline-rich domain of p53 and increases following genotoxic stress.p21-dependent inhibition of colon cancer cell growth by mevastatin is independent of inhibition of G1 cyclin-dependent kinases.Oncogenic point mutations in exon 20 of the RB1 gene in families showing incomplete penetrance and mild expression of the retinoblastoma phenotypeLack of inverse dose-rate effect and binding of the retinoblastoma gene product in the nucleus of human cancer T-47D cells arrested in G2 by ionizing radiation.p35 is required for CDK5 activation in cellular senescence.Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.Nuclear localization is required for function of the essential clock protein FRQ.The human oncoprotein MDM2 arrests the cell cycle: elimination of its cell-cycle-inhibitory function induces tumorigenesisProgesterone inhibits estrogen-induced cyclin D1 and cdk4 nuclear translocation, cyclin E- and cyclin A-cdk2 kinase activation, and cell proliferation in uterine epithelial cells in miceDNA damage-dependent nuclear dynamics of the Mre11 complexProtein kinase A and C site-specific phosphorylations of LAP (NF-IL6) modulate its binding affinity to DNA recognition elements.An extracellular signal-regulated kinase 1- and 2-dependent program of chromatin trafficking of c-Fos and Fra-1 is required for cyclin D1 expression during cell cycle reentry.The impact of CDK inhibition in human malignancies associated with pronounced defects in apoptosis: advantages of multi-targeting small molecules.MyoD induced cell cycle arrest is associated with increased nuclear affinity of the Rb protein.Cell cycle-regulated degradation of Xenopus cyclin B2 requires binding to p34cdc2.The G1 phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification.Structural insights into the mechanism of phosphoregulation of the retinoblastoma proteinNucleoplasmic lamins and their interaction partners, LAP2alpha, Rb, and BAF, in transcriptional regulation.The retinoblastoma gene product is a cell cycle-dependent, nuclear matrix-associated protein.The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies.Further characterization of retinoblastoma gene-mediated cell growth and tumor suppression in human cancer cellsLimited redundancy in phosphorylation of retinoblastoma tumor suppressor protein by cyclin-dependent kinases in acute lymphoblastic leukemiaNuclear protein phosphorylation and growth control.
P2860
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P2860
G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
G1/S phosphorylation of the re ...... y for the nuclear compartment.
@en
type
label
G1/S phosphorylation of the re ...... y for the nuclear compartment.
@en
prefLabel
G1/S phosphorylation of the re ...... y for the nuclear compartment.
@en
P1433
P1476
G1/S phosphorylation of the re ...... y for the nuclear compartment.
@en
P2093
Mittnacht S
Weinberg RA
P304
P356
10.1016/0092-8674(91)90456-9
P407
P577
1991-05-01T00:00:00Z