A mutant form of human protein farnesyltransferase exhibits increased resistance to farnesyltransferase inhibitors. - Wikidata - awgldk - TriplyDB

A mutant form of human protein farnesyltransferase exhibits increased resistance to farnesyltransferase inhibitors.

A mutant form of human protein farnesyltransferase exhibits increased resistance to farnesyltransferase inhibitors.

http://www.wikidata.org/entity/Q41689650

about

The protein farnesyltransferase regulates HDAC6 activity in a microtubule-dependent manner Farnesyl transferase inhibitor resistance probed by target mutagenesis Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase Therapeutic efficacy of prenylation inhibitors in the treatment of myeloid leukemia.Development of farnesyltransferase inhibitors for clinical cancer therapy: focus on hematologic malignancies.Tipifarnib in the treatment of newly diagnosed acute myelogenous leukemia.Tumor cell migration and invasion are regulated by expression of variant integrin glycoforms Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe.Resistance to farnesyltransferase inhibitors in Bcr/Abl-positive lymphoblastic leukemia by increased expression of a novel ABC transporter homolog ATP11a.Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum.

P2860

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P2860

A mutant form of human protein farnesyltransferase exhibits increased resistance to farnesyltransferase inhibitors.

http://www.wikidata.org/entity/Q41689650

description

1999 nî lūn-bûn

@nan

1999年の論文

@ja

1999年論文

@yue

1999年論文

@zh-hant

1999年論文

@zh-hk

1999年論文

@zh-mo

1999年論文

@zh-tw

1999年论文

@wuu

1999年论文

@zh

1999年论文

@zh-cn

name

A mutant form of human protein ...... arnesyltransferase inhibitors.

@en

type

label

A mutant form of human protein ...... arnesyltransferase inhibitors.

@en

prefLabel

A mutant form of human protein ...... arnesyltransferase inhibitors.

@en

P1433

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P2093

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P2860

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P698

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P356

JBC.274.38.27010

P1433

Journal of Biological Chemistry

P1476

A mutant form of human protein ...... arnesyltransferase inhibitors.

@en

P2093

Del Villar K

http://www.w3.org/2001/XMLSchema#string

Guo L

http://www.w3.org/2001/XMLSchema#string

Tamanoi F

http://www.w3.org/2001/XMLSchema#string

Urano J

http://www.w3.org/2001/XMLSchema#string

P2860

Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution

Protein farnesyltransferase: structure and implications for substrate binding

Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate

Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

Protein geranylgeranyltransferase of Saccharomyces cerevisiae is specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43 gene product but not the DPR1 gene product

Improved method for high efficiency transformation of intact yeast cells

Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice

Protein prenylation: molecular mechanisms and functional consequences

Farnesyltransferase inhibitors induce cytochrome c release and caspase 3 activation preferentially in transformed cells.

P304

27010-27017

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.274.38.27010

http://www.w3.org/2001/XMLSchema#string

P407

P433

38

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P478

274

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P577

1999-09-01T00:00:00Z

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P5875

12819053

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P698

10480914

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