Termination of DNA synthesis by 9-beta-D-arabinofuranosyl-2-fluoroadenine. A mechanism for cytotoxicity.
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Enzymology of purine and pyrimidine antimetabolites used in the treatment of cancerFludarabine in the treatment of chronic lymphocytic leukemia: a reviewSynergistic Activity of Deguelin and Fludarabine in Cells from Chronic Lymphocytic Leukemia Patients and in the New Zealand Black Murine ModelEvaluating the Therapeutic Potential of a Non-Natural Nucleotide That Inhibits Human Ribonucleotide Reductase4'-Acylated thymidine 5'-triphosphates: a tool to increase selectivity towards HIV-1 reverse transcriptasePolyadenylation inhibition by the triphosphates of deoxyadenosine analogues.Evaluation of bendamustine in combination with fludarabine in primary chronic lymphocytic leukemia cells.The structural basis for the allosteric regulation of ribonucleotide reductase.Deconstructing nucleotide binding activity of the Mdm2 RING domain.The synergistic cytotoxicity of clofarabine, fludarabine and busulfan in AML cells involves ATM pathway activation and chromatin remodelingAlteration of the carbohydrate for deoxyguanosine analogs markedly changes DNA replication fidelity, cell cycle progression and cytotoxicityInterstrand crosslink inducing agents in pretransplant conditioning therapy for hematologic malignancies.DNA repair mechanisms in cancer development and therapyFludarabine increases oxaliplatin cytotoxicity in normal and chronic lymphocytic leukemia lymphocytes by suppressing interstrand DNA crosslink removalFialuridine accumulates in DNA of dogs, monkeys, and rats following long-term oral administration.A non-natural nucleoside with combined therapeutic and diagnostic activities against leukemiaTargeting the Large Subunit of Human Ribonucleotide Reductase for Cancer Chemotherapy.Identification of Non-nucleoside Human Ribonucleotide Reductase ModulatorsFludarabine combined with radiotherapy in patients with locally advanced NSCLC lung carcinoma: a phase I study.Resistance to the nucleotide analogue cidofovir in HPV(+) cells: a multifactorial process involving UMP/CMP kinase 1Role of histone deacetylase inhibitor-induced reactive oxygen species and DNA damage in LAQ-824/fludarabine antileukemic interactions.DNA polymerases as therapeutic targetsDNA damage and repair in human cancer: molecular mechanisms and contribution to therapy-related leukemias.Differential effects of the incorporation of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodouracil (FIAU) on the binding of the transcription factors, AP-1 and TFIID, to their cognate target DNA sequences.Microdose-Induced Drug-DNA Adducts as Biomarkers of Chemotherapy Resistance in Humans and Mice.Killing of chronic lymphocytic leukemia by the combination of fludarabine and oxaliplatin is dependent on the activity of XPF endonuclease3'-azido-3'-deoxythymidine (AZT) monophosphate: an inhibitor of exonucleolytic repair of AZT-terminated DNA9-(2'-Deoxy-2'-Fluoro-β-d-Arabinofuranosyl) Adenine Is a Potent Antitrypanosomal Adenosine Analogue That Circumvents Transport-Related Drug Resistance.Inhibition of nucleotide excision repair by fludarabine in normal lymphocytes in vitro, measured by the alkaline single cell gel electrophoresis (Comet) assay.Inhibiting DNA Polymerases as a Therapeutic Intervention against Cancer.Phase I clinical trial of the base excision repair inhibitor methoxyamine in combination with fludarabine for patients with advanced hematologic malignancies.Nucleobase and Nucleoside Analogues: Resistance and Re-Sensitisation at the Level of Pharmacokinetics, Pharmacodynamics and Metabolism
P2860
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P2860
Termination of DNA synthesis by 9-beta-D-arabinofuranosyl-2-fluoroadenine. A mechanism for cytotoxicity.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
Termination of DNA synthesis b ...... A mechanism for cytotoxicity.
@en
type
label
Termination of DNA synthesis b ...... A mechanism for cytotoxicity.
@en
prefLabel
Termination of DNA synthesis b ...... A mechanism for cytotoxicity.
@en
P2093
P1476
Termination of DNA synthesis b ...... A mechanism for cytotoxicity.
@en
P2093
P304
16617-16625
P407
P577
1990-09-01T00:00:00Z