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How MCM loading and spreading specify eukaryotic DNA replication initiation sitesAnti-tumor effects of novel 5-O-acyl plumbagins based on the inhibition of mammalian DNA replicative polymerase activityReal-time single-molecule observation of rolling-circle DNA replication.The dominant role of proofreading exonuclease activity of replicative polymerase ε in cellular tolerance to cytarabine (Ara-C)InTERTpreting telomerase structure and functionSubtractive genomics approach to identify putative drug targets and identification of drug-like molecules for beta subunit of DNA polymerase III in Streptococcus species.A Bioorthogonal Chemical Reporter of Viral Infection.A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.Identifying initiation and elongation inhibitors of dengue virus RNA polymerase in a high-throughput lead-finding campaign.A metal-containing nucleoside that possesses both therapeutic and diagnostic activity against cancerArchitecture and conservation of the bacterial DNA replication machinery, an underexploited drug target.Mutations conferring resistance to viral DNA polymerase inhibitors in camelpox virus give different drug-susceptibility profiles in vaccinia virus.Oral administration of monogalactosyl diacylglycerol from spinach inhibits colon tumor growth in mice.Probing the ATP Site of GRP78 with Nucleotide Triphosphate Analogs.TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs.Microfluidic-assisted analysis of replicating DNA moleculesTargeting DNA polymerase ß for therapeutic intervention.From bench to bedside: the growing use of translational research in cancer medicine.Alternative approaches to antiviral treatments: focusing on glycosylation as a target for antiviral therapy.Towards novel paradigms for cancer therapy.Chemical Incorporation of Chain-Terminating Nucleoside Analogs as 3'-Blocking DNA Damage and Their Removal by Human ERCC1-XPF Endonuclease.Participation of translesion synthesis DNA polymerases in the maintenance of chromosome integrity in yeast Saccharomyces cerevisiae.Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides.PrimPol-Prime Time to Reprime.Cyclometalated iridium(III) complexes with deoxyribose substituents.Bacteria under SOS evolve anticancer phenotypes.5',6'-nucleoside phosphonate analogues architecture: synthesis and comparative evaluation towards metabolic enzymes.Targeting translesion synthesis to facilitate the eradication of ovarian cancer stem cells by platinum-based therapy.Enthalpy-entropy contribution to carcinogen-induced DNA conformational heterogeneityReplication of the 2,6-diamino-4-hydroxy-N(5)-(methyl)-formamidopyrimidine (MeFapy-dGuo) adduct by eukaryotic DNA polymerases.Rapid incorporation kinetics and improved fidelity of a novel class of 3'-OH unblocked reversible terminators.Adapting capillary gel electrophoresis as a sensitive, high-throughput method to accelerate characterization of nucleic acid metabolic enzymes.Structural basis for DNA 3'-end processing by human tyrosyl-DNA phosphodiesterase 1.Second-Shell Basic Residues Expand the Two-Metal-Ion Architecture of DNA and RNA Processing Enzymes.Role of chromatin damage and chromatin trapping of FACT in mediating the anticancer cytotoxicity of DNA-binding small molecule drugs.The Human Replicative Helicase, the CMG Complex, as a Target for Anti-cancer Therapy.A facile graphene oxide-based DNA polymerase assay.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 19 July 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
DNA polymerases as therapeutic targets
@en
DNA polymerases as therapeutic targets.
@nl
type
label
DNA polymerases as therapeutic targets
@en
DNA polymerases as therapeutic targets.
@nl
prefLabel
DNA polymerases as therapeutic targets
@en
DNA polymerases as therapeutic targets.
@nl
P2860
P356
P1433
P1476
DNA polymerases as therapeutic targets
@en
P2093
Anthony J Berdis
P2860
P304
P356
10.1021/BI801179F
P407
P577
2008-07-19T00:00:00Z