RGS4 is arginylated and degraded by the N-end rule pathway in vitro.
about
A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.The N-end rule pathwayDiscovery of cellular regulation by protein degradationGalphao/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathwaysDiversity of degradation signals in the ubiquitin-proteasome systemFemale lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathwaySynthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathwayPromotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIPμ-Opioid receptors and regulators of G protein signaling (RGS) proteins: from a symposium on new concepts in mu-opioid pharmacologyRegulators of G-protein signaling in the heart and their potential as therapeutic targets.Src-mediated RGS16 tyrosine phosphorylation promotes RGS16 stabilityIdentification of mammalian arginyltransferases that modify a specific subset of protein substratesSplicing factor transformer-2β (Tra2β) regulates the expression of regulator of G protein signaling 4 (RGS4) gene and is induced by morphineConstruction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathwayFBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex.Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets.The evolution of regulators of G protein signalling proteins as drug targets - 20 years in the making: IUPHAR Review 21.Small molecule inhibitors of arginyltransferase regulate arginylation-dependent protein degradation, cell motility, and angiogenesisRab family proteins regulate the endosomal trafficking and function of RGS4.Gamma 2 subunit of G protein heterotrimer is an N-end rule ubiquitylation substrate.Growth inhibition of human breast carcinoma cells by overexpression of regulator of G-protein signaling 4.Identification and characterization of regulator of G protein signaling 4 (RGS4) as a novel inhibitor of tubulogenesis: RGS4 inhibits mitogen-activated protein kinases and vascular endothelial growth factor signaling.Protein arginylation, a global biological regulator that targets actin cytoskeleton and the muscleRGS4 and RGS5 are in vivo substrates of the N-end rule pathwayRGS14 is a bifunctional regulator of Galphai/o activity that exists in multiple populations in brain.Regulator of G-protein signaling protein 2 modulates purinergic calcium and ciliary beat frequency responses in airway epithelia.The N-end rule pathway and regulation by proteolysisThinking outside of the "RGS box": new approaches to therapeutic targeting of regulators of G protein signaling.Dissection of c-MOS degronDHHC protein-dependent palmitoylation protects regulator of G-protein signaling 4 from proteasome degradation.Pairs of dipeptides synergistically activate the binding of substrate by ubiquitin ligase through dissociation of its autoinhibitory domain.Control of protein life-span by N-terminal methionine excisionArginyltransferase is an ATP-independent self-regulating enzyme that forms distinct functional complexes in vivo.Phosphorylation of RGS13 by the cyclic AMP-dependent protein kinase inhibits RGS13 degradationOpioid-induced down-regulation of RGS4: role of ubiquitination and implications for receptor cross-talk.Regulators of G protein signaling (RGS) proteins as drug targets: modulating G-protein-coupled receptor (GPCR) signal transductionAbsence of the Regulator of G-protein Signaling, RGS4, Predisposes to Atrial Fibrillation and Is Associated with Abnormal Calcium HandlingArginylation-dependent regulation of a proteolytic product of talin is essential for cell-cell adhesion.Characterization of arginylation branch of N-end rule pathway in G-protein-mediated proliferation and signaling of cardiomyocytesAmino-terminal cysteine residues differentially influence RGS4 protein plasma membrane targeting, intracellular trafficking, and function
P2860
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P2860
RGS4 is arginylated and degraded by the N-end rule pathway in vitro.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
RGS4 is arginylated and degraded by the N-end rule pathway in vitro.
@en
type
label
RGS4 is arginylated and degraded by the N-end rule pathway in vitro.
@en
prefLabel
RGS4 is arginylated and degraded by the N-end rule pathway in vitro.
@en
P2860
P356
P1476
RGS4 is arginylated and degraded by the N-end rule pathway in vitro.
@en
P2093
Davydov IV
Varshavsky A
P2860
P304
22931-22941
P356
10.1074/JBC.M001605200
P407
P577
2000-07-01T00:00:00Z