Inhibition of serum- and ras-stimulated DNA synthesis by antibodies to phospholipase C.
about
Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomasRequirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: evidence for the existence of Ras-dependent and Ras-independent pathwaysNovel peptides from the RAS-p21 and p53 proteins for the treatment of cancerRegulation of EGF-induced phospholipase C-gamma1 translocation and activation by its SH2 and PH domainsThe erbB-2 mitogenic signaling pathway: tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does not correlate with erbB-2 mitogenic potencyRequirement for phospholipase C-gamma1 enzymatic activity in growth factor-induced mitogenesisras-p21-induced cell transformation: unique signal transduction pathways and implications for the design of new chemotherapeutic agents.Sprouty proteins inhibit receptor-mediated activation of phosphatidylinositol-specific phospholipase C.Blocking oncogenic Ras signaling for cancer therapy.Inositol-lipid-specific phospholipase C isoenzymes and their differential regulation by receptorsPhospholipase C-gamma 1 can induce DNA synthesis by a mechanism independent of its lipase activity.Mitogenic pathways regulated by G protein oncogenes.Mediation of growth factor induced DNA synthesis and calcium mobilization by Gq and Gi2Regulation of intracellular actin polymerization by prenylated cellular proteins.The GTPase-activating protein of Ras suppresses platelet-derived growth factor beta receptor signaling by silencing phospholipase C-gamma 1Platelet-derived growth factor increases the in vivo activity of phospholipase C-gamma 1 and phospholipase C-gamma 2Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cellsEpidermal growth factor signaling and mitogenesis in Plcg1 null mouse embryonic fibroblasts.Evidence that the ras oncogene-encoded p21 protein induces oocyte maturation via activation of protein kinase C.The biochemistry of ras p21.Immunocytochemical localization of phospholipase C-gamma in rat embryo fibroblasts.Inhibition of the EGF-induced activation of phospholipase C-gamma1 by a single chain antibody fragment.Disruption of gap junctional communication by the platelet-derived growth factor is mediated via multiple signaling pathways.Mutations at residues Tyr771 and Tyr783 of phospholipase C-gamma1 have different effects on cell actin-cytoskeleton organization and cell proliferation in CCL-39 cells.p21ras and protein kinase C function in distinct and interdependent signaling pathways in C3H 10T1/2 fibroblasts.Microinjected cDNA encoding JAK2 protein-tyrosine kinase induces DNA synthesis in NIH 3T3 cells.Molecular dynamics of the H-ras gene-encoded p21 protein; identification of flexible regions and possible effector domains.Differential Ca2+ signaling induced by activation of the epidermal growth factor and nerve growth factor receptors.Nitric oxide action on growth factor-elicited signals. Phosphoinositide hydrolysis and [Ca2+]i responses are negatively modulated via a cGMP-dependent protein kinase I pathway.Platelet-derived growth factor-dependent association of the GTPase-activating protein of Ras and Src.Phospholipase activity of phospholipase C-gamma1 is required for nerve growth factor-regulated MAP kinase signaling cascade in PC12 cells.Microinjection of a p21ras antibody into PC12 cells inhibits neurite outgrowth induced by nerve growth factor and basic fibroblast growth factor.Fibroblast growth factor acts upon the transcription of phospholipase C genes in human umbilical vein endothelial cells.
P2860
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P2860
Inhibition of serum- and ras-stimulated DNA synthesis by antibodies to phospholipase C.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
Inhibition of serum- and ras-stimulated DNA synthesis by antibodies to phospholipase C.
@en
type
label
Inhibition of serum- and ras-stimulated DNA synthesis by antibodies to phospholipase C.
@en
prefLabel
Inhibition of serum- and ras-stimulated DNA synthesis by antibodies to phospholipase C.
@en
P2093
P356
P1433
P1476
Inhibition of serum- and ras-stimulated DNA synthesis by antibodies to phospholipase C.
@en
P2093
P304
P356
10.1126/SCIENCE.2408147
P407
P577
1990-03-01T00:00:00Z