Phospholipase C-gamma 1 can induce DNA synthesis by a mechanism independent of its lipase activity. - Wikidata - awgldk - TriplyDB

Phospholipase C-gamma 1 can induce DNA synthesis by a mechanism independent of its lipase activity.

Phospholipase C-gamma 1 can induce DNA synthesis by a mechanism independent of its lipase activity.

http://www.wikidata.org/entity/Q35582318

about

Role of the pleckstrin homology domain of PLCgamma1 in its interaction with the insulin receptor Transmodulation between phospholipase D and c-Src enhances cell proliferation PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion Semaphorin 4D signaling requires the recruitment of phospholipase C gamma into the plexin-B1 receptor complex.Structural basis for recognition of the T cell adaptor protein SLP-76 by the SH3 domain of phospholipase Cgamma1 Structural characterization of the split pleckstrin homology domain in phospholipase C-gamma1 and its interaction with TRPC3.Pleiotropic contributions of phospholipase C-gamma1 (PLC-gamma1) to T-cell antigen receptor-mediated signaling: reconstitution studies of a PLC-gamma1-deficient Jurkat T-cell line ras-p21-induced cell transformation: unique signal transduction pathways and implications for the design of new chemotherapeutic agents.Phospholipase C-gamma1 is required for the epidermal growth factor receptor-induced squamous cell carcinoma cell mitogenesis.Mutagenesis of active-site histidines of Listeria monocytogenes phosphatidylinositol-specific phospholipase C: effects on enzyme activity and biological function.Insulin receptor-mediated signaling via phospholipase C-γ regulates growth and differentiation in Drosophila Somatic DNA Hypomethylation in H. pylori-Associated High-Risk Gastritis and Gastric Cancer: Enhanced Somatic Hypomethylation Associates with Advanced Stage Cancer.Amplification of receptor signalling by Ca2+ entry-mediated translocation and activation of PLCgamma2 in B lymphocytes.Phospholipase Cγ2 plays a role in TCR signal transduction and T cell selection.PIKE GTPase are phosphoinositide-3-kinase enhancers, suppressing programmed cell death.Phospholipase C-gamma binds directly to the Na+/H+ exchanger 3 and is required for calcium regulation of exchange activity.Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2.PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2.A double point mutation in PCL-gamma1 (Y509A/F510A) enhances Y783 phosphorylation and inositol phospholipid-hydrolyzing activity upon EGF stimulation.An important role of phospholipase Cgamma1 in pre-B-cell development and allelic exclusion.Matrix-independent activation of phosphatidylinositol 3-kinase, Stat3, and cyclin A-associated Cdk2 Is essential for anchorage-independent growth of v-Ros-transformed chicken embryo fibroblasts.HIV-1 Nef interacts with inositol trisphosphate receptor to activate calcium signaling in T cells.Inhibition of the EGF-induced activation of phospholipase C-gamma1 by a single chain antibody fragment.Differential roles of the Src homology 2 domains of phospholipase C-gamma1 (PLC-gamma1) in platelet-derived growth factor-induced activation of PLC-gamma1 in intact cells.Phospholipase Cγ1 Mediates Intima Formation Through Akt-Notch1 Signaling Independent of the Phospholipase Activity.PLCgamma2 Activates CREB-dependent Transcription in PC12 Cells Through Phosphorylation of CREB at Serine 133 Platelet-derived growth factor-dependent association of the GTPase-activating protein of Ras and Src.Phospholipase activity of phospholipase C-gamma1 is required for nerve growth factor-regulated MAP kinase signaling cascade in PC12 cells.A PIP2-derived amplification loop fuels the sustained initiation of B cell activation.The binding of activated Gαq to phospholipase C-β exhibits anomalous affinity.Phospholipase Cγ1 links inflammation and tumorigenesis in colitis-associated cancer.Polyomavirus middle T antigen as a probe for T cell antigen receptor-coupled signaling pathways.Fibroblast growth factor receptor 3 isoforms: Novel therapeutic targets for hepatocellular carcinoma?Prolonged protein turnover of glyceraldehyde-3-phosphate dehydrogenase by phospholipase C-gamma 1 is critical for anchorage-independent growth and ATP synthesis in transformed cells.Identification of three polymorphisms in the translated region of PLC-gamma1 and their investigation in lithium responsive bipolar disorder.

P2860

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P2860

Phospholipase C-gamma 1 can induce DNA synthesis by a mechanism independent of its lipase activity.

http://www.wikidata.org/entity/Q35582318

description

1994 nî lūn-bûn

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P1433

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PNAS.91.14.6554

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Proceedings of the National Academy of Sciences of the United States of America

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Kung HF

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P2860

A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1

The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment

Phosphorylation of Nck in response to a variety of receptors, phorbol myristate acetate, and cyclic AMP

Rapid and efficient site-specific mutagenesis without phenotypic selection

SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins

Regulation of inositol phospholipid-specific phospholipase C isozymes

Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors

Inositol trisphosphate, a novel second messenger in cellular signal transduction

Effects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src.

The C-terminal SH2 domain of p85 accounts for the high affinity and specificity of the binding of phosphatidylinositol 3-kinase to phosphorylated platelet-derived growth factor beta receptor.

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6554-6558

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91

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15176065

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8022819

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44241

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