Evidence for the prion hypothesis: induction of the yeast [PSI+] factor by in vitro- converted Sup35 protein.
about
Amyloid aggregates of the HET-s prion protein are infectious.A systematic survey identifies prions and illuminates sequence features of prionogenic proteinsFormation of native prions from minimal components in vitroMechanism of prion propagation: amyloid growth occurs by monomer additionThe mechanism of prion strain propagationTwo different neurodegenerative diseases caused by proteins with similar structuresAn amyloid-forming peptide from the yeast prion Sup35 reveals a dehydrated beta-sheet structure for amyloidScreening for toxic amyloid in yeast exemplifies the role of alternative pathway responsible for cytotoxicityDe novo [PSI +] prion formation involves multiple pathways to form infectious oligomers.Strong growth polarity of yeast prion fiber revealed by single fiber imaging.Function of SSA subfamily of Hsp70 within and across species varies widely in complementing Saccharomyces cerevisiae cell growth and prion propagation.Measurement of amyloid fibril mass-per-length by tilted-beam transmission electron microscopy.Glycosylphosphatidylinositol anchoring directs the assembly of Sup35NM protein into non-fibrillar, membrane-bound aggregatesBiology and genetics of prions causing neurodegenerationDistinct prion strains are defined by amyloid core structure and chaperone binding site dynamics.Search for a prion-specific nucleic acid.Conversion of a yeast prion protein to an infectious form in bacteriaInduction of distinct [URE3] yeast prion strains.Progress toward an ultimate proof of the prion hypothesis.Exploring the propensities of helices in PrP(C) to form beta sheet using NMR structures and sequence alignmentsPrions.Orientation of aromatic residues in amyloid cores: structural insights into prion fiber diversityRadically different amyloid conformations dictate the seeding specificity of a chimeric Sup35 prion.Correlation of structural elements and infectivity of the HET-s prion.Recent developments in the pathogenesis, diagnosis, and therapy of prion diseases.Propagation of yeast prions.Purified and synthetic Alzheimer's amyloid beta (Aβ) prions.The ribosome-associated complex antagonizes prion formation in yeast.Prions in yeast.Role of Hsp104 in the propagation and inheritance of the [Het-s] prion.Strain conformation, primary structure and the propagation of the yeast prion [PSI+].The elongation of yeast prion fibers involves separable steps of association and conversion.Molecular dynamics simulations of alanine rich beta-sheet oligomers: Insight into amyloid formation.The reconstitution of mammalian prion infectivity de novo.Mutant PrPSc conformers induced by a synthetic peptide and several prion strainsSaccharomyces cerevisiae: a sexy yeast with a prion problem.Infectious fold and amyloid propagation in Podospora anserina.Design and construction of diverse mammalian prion strainsLife cycle of cytosolic prions.Classifying prion and prion-like phenomena.
P2860
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P2860
Evidence for the prion hypothesis: induction of the yeast [PSI+] factor by in vitro- converted Sup35 protein.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Evidence for the prion hypothe ...... itro- converted Sup35 protein.
@en
type
label
Evidence for the prion hypothe ...... itro- converted Sup35 protein.
@en
prefLabel
Evidence for the prion hypothe ...... itro- converted Sup35 protein.
@en
P2093
P1433
P1476
Evidence for the prion hypothe ...... itro- converted Sup35 protein.
@en
P2093
Sparrer HE
Szoka FC Jr
Weissman JS
P304
P356
10.1126/SCIENCE.289.5479.595
P407
P577
2000-07-01T00:00:00Z