about
Mitochondria-controlled signaling mechanisms of brain protection in hypoxiaGPR91: expanding the frontiers of Krebs cycle intermediatesConstruction and analysis of correlation networks based on gas chromatography-mass spectrometry metabonomics data for lipopolysaccharide-induced inflammation and intervention with volatile oil from Angelica sinensis in rats.ERK1/2/COX-2/PGE2 signaling pathway mediates GPR91-dependent VEGF release in streptozotocin-induced diabetes.The succinate receptor as a novel therapeutic target for oxidative and metabolic stress-related conditionsMetabolic control of renin secretionSuccinate causes pathological cardiomyocyte hypertrophy through GPR91 activation.Identification of lead compounds for (99m)Tc and (18)F GPR91 radiotracersThe MAPK signaling pathway mediates the GPR91-dependent release of VEGF from RGC-5 cells.Angiotensin receptor blockade recovers hepatic UCP2 expression and aconitase and SDH activities and ameliorates hepatic oxidative damage in insulin resistant rats.Regulation of Vascular and Renal Function by Metabolite ReceptorsSirtuin 3 (SIRT3) Regulates α-Smooth Muscle Actin (α-SMA) Production through the Succinate Dehydrogenase-G Protein-coupled Receptor 91 (GPR91) Pathway in Hepatic Stellate Cells.Activation of the succinate receptor GPR91 in macula densa cells causes renin release.GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis.Oncometabolite succinate promotes angiogenesis by upregulating VEGF expression through GPR91-mediated STAT3 and ERK activation.Sodium-coupled dicarboxylate and citrate transporters from the SLC13 family.Unsung renal receptors: orphan G-protein-coupled receptors play essential roles in renal development and homeostasis.G protein-coupled receptor 91 signaling in diabetic retinopathy and hypoxic retinal diseases.GPR91 deficiency exacerbates allergic contact dermatitis while reducing arthritic disease in mice.The role of the GPR91 ligand succinate in hematopoiesis.Specific Features of Immediate Expression of Succinate-Dependent Receptor GPR91 in Tissues during Hypoxia.Activation of the renal renin-angiotensin system in diabetes--new concepts.Succinate receptor GPR91, a Gα(i) coupled receptor that increases intracellular calcium concentrations through PLCβ.Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91.LY2405319, an analog of fibroblast growth factor 21 ameliorates α-smooth muscle actin production through inhibition of the succinate-G-protein couple receptor 91 (GPR91) pathway in mice.Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota.Succinate induces aberrant mitochondrial fission in cardiomyocytes through GPR91 signaling.Multiple faces of succinate beyond metabolism in bloodSuccinate as a Regulator of Hepatic Stellate Cells in Liver Fibrosis
P2860
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P2860
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Succinate is a paracrine signal for liver damage.
@en
type
label
Succinate is a paracrine signal for liver damage.
@en
prefLabel
Succinate is a paracrine signal for liver damage.
@en
P2093
P2860
P1476
Succinate is a paracrine signal for liver damage.
@en
P2093
Emma A Kruglov
Jonathan A Dranoff
M Fatima Leite
Mayerson Thompson
Michael H Nathanson
Paulo Renato A V Correa
P2860
P304
P356
10.1016/J.JHEP.2007.03.016
P577
2007-04-05T00:00:00Z