Rosiglitazone rescues memory impairment in Alzheimer's transgenic mice: mechanisms involving a reduced amyloid and tau pathology. - Wikidata - awgldk - TriplyDB

Rosiglitazone rescues memory impairment in Alzheimer's transgenic mice: mechanisms involving a reduced amyloid and tau pathology.

Rosiglitazone rescues memory impairment in Alzheimer's transgenic mice: mechanisms involving a reduced amyloid and tau pathology.

http://www.wikidata.org/entity/Q41762801

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PPARγ and the Innate Immune System Mediate the Resolution of Inflammation Insulin: an emerging treatment for Alzheimer's disease dementia?Intranasal insulin therapy for cognitive impairment and neurodegeneration: current state of the art Elevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brain Insulin resistance as a key link for the increased risk of cognitive impairment in the metabolic syndrome Alzheimer Disease: Crosstalk between the Canonical Wnt/Beta-Catenin Pathway and PPARs Alpha and Gamma Bezafibrate administration improves behavioral deficits and tau pathology in P301S mice Influence of drug transporters and stereoselectivity on the brain penetration of pioglitazone as a potential medicine against Alzheimer's disease Neuroinflammation and M2 microglia: the good, the bad, and the inflamed.Alzheimer's disease: relevant molecular and physiopathological events affecting amyloid-β brain balance and the putative role of PPARs.Nuclear receptors in neurodegenerative diseases.Insulin resistance in Alzheimer's disease.Ginsenoside Rg1 decreases Aβ(1-42) level by upregulating PPARγ and IDE expression in the hippocampus of a rat model of Alzheimer's disease.The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain.Role of cerebrospinal fluid biomarkers in clinical trials for Alzheimer's disease modifying therapies Fatty acid synthase as a factor required for exercise-induced cognitive enhancement and dentate gyrus cellular proliferation.The evolving biology of microglia in Alzheimer's disease.Nuclear receptors as therapeutic targets for Alzheimer's disease Impaired firing properties of dentate granule neurons in an Alzheimer's disease animal model are rescued by PPARγ agonism.The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease.An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers.Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of Alzheimer's disease Combined Liver X Receptor/Peroxisome Proliferator-activated Receptor γ Agonist Treatment Reduces Amyloid β Levels and Improves Behavior in Amyloid Precursor Protein/Presenilin 1 Mice Mechanisms underlying the rapid peroxisome proliferator-activated receptor-γ-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease.Altered APP processing in insulin-resistant conditions is mediated by autophagosome accumulation via the inhibition of mammalian target of rapamycin pathway.Cognitive enhancement with rosiglitazone links the hippocampal PPARγ and ERK MAPK signaling pathways.Protective Effects of Liquiritin on the Brain of Rats with Alzheimer's Disease Rosiglitazone ameliorates diffuse axonal injury by reducing loss of tau and up-regulating caveolin-1 expression.Type 2 diabetes and cognitive compromise: potential roles of diabetes-related therapies.Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer's disease.Neuroprotective effects of sodium hydrosulfide against β-amyloid-induced neurotoxicity.PPAR agonists as therapeutics for CNS trauma and neurological diseases Cognitive enhancing treatment with a PPARγ agonist normalizes dentate granule cell presynaptic function in Tg2576 APP mice.The Nuclear Receptor PPARgamma as a Therapeutic Target for Cerebrovascular and Brain Dysfunction in Alzheimer's Disease What have we learned from the streptozotocin-induced animal model of sporadic Alzheimer's disease, about the therapeutic strategies in Alzheimer's research.A review: treatment of Alzheimer's disease discovered in repurposed agents.Insulin dysfunction and Tau pathology.Apolipoprotein E as a Therapeutic Target in Alzheimer's Disease: A Review of Basic Research and Clinical Evidence Therapeutic Actions of the Thiazolidinediones in Alzheimer's Disease.PPARgamma agonists rescue increased phosphorylation of FGF14 at S226 in the Tg2576 mouse model of Alzheimer's disease.

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Rosiglitazone rescues memory impairment in Alzheimer's transgenic mice: mechanisms involving a reduced amyloid and tau pathology.

http://www.wikidata.org/entity/Q41762801

description

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Rosiglitazone rescues memory i ...... ced amyloid and tau pathology.

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Rosiglitazone rescues memory i ...... ced amyloid and tau pathology.

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Rosiglitazone rescues memory i ...... ced amyloid and tau pathology.

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Rosiglitazone rescues memory i ...... ced amyloid and tau pathology.

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Ana-María Simón

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Diana Frechilla

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Esther Gimeno

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Joaquín Del Río

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Luis Escribano

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Rakel López de Maturana

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P2860

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

ApoE promotes the proteolytic degradation of Abeta

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme

STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's beta-amyloid deposits

Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme

A specific amyloid-beta protein assembly in the brain impairs memory

An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

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