Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity.

Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity.

Item
http://www.wikidata.org/entity/Q41806994
Detection of cytochrome P450 mRNA transcripts in prostate samples by RT-PCRInfluence of phenylalanine-481 substitutions on the catalytic activity of cytochrome P450 2D6New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme.A discordance between cytochrome P450 2D6 genotype and phenotype in patients undergoing methadone maintenance treatment.Enzyme Tunnels and Gates As Relevant Targets in Drug Design.Compensatory changes in CYP expression in three different toxicology mouse models: CAR-null, Cyp3a-null, and Cyp2b9/10/13-null miceInsights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions.Repression of multiple CYP2D genes in mouse primary hepatocytes with a single siRNA constructEngineering and assaying of cytochrome P450 biocatalysts.The active site of the thermophilic CYP119 from Sulfolobus solfataricus.Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.Impact of incorporating the 2C5 crystal structure into comparative models of cytochrome P450 2D6.Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.Porcine microsomal vitamin D(3) 25-hydroxylase (CYP2D25). Catalytic properties, tissue distribution, and comparison with human CYP2D6.Microsecond MD simulations of human CYP2D6 wild-type and five allelic variants reveal mechanistic insights on the function
P2860

Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity.

Item
http://www.wikidata.org/entity/Q41806994
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Determinants of the substrate ...... osterone hydroxylase activity.
@en
type
label
Determinants of the substrate ...... osterone hydroxylase activity.
@en
prefLabel
Determinants of the substrate ...... osterone hydroxylase activity.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P478
P577
P5875
P698
P932
P356
P1433
P1476
Determinants of the substrate ...... osterone hydroxylase activity.
@en
P2093
P2860
P304
P31
P356
P407
P478
P577
P5875
P698
P932