A chemical genetic approach reveals that p38alpha MAPK activation by diphosphorylation aggravates myocardial infarction and is prevented by the direct binding of SB203580.
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p38 MAPK in cardioprotection - are we there yet?Mechanism and consequence of the autoactivation of p38α mitogen-activated protein kinase promoted by TAB1The p38 mitogen-activated protein kinase pathway--a potential target for intervention in infarction, hypertrophy, and heart failure.Crosstalk between mitogen-activated protein kinases and mitochondria in cardiac diseases: therapeutic perspectivesA sphingosine kinase form 2 knockout sensitizes mouse myocardium to ischemia/reoxygenation injury and diminishes responsiveness to ischemic preconditioning.Role of Mitogen-Activated Protein Kinases in Myocardial Ischemia-Reperfusion Injury during Heart TransplantationBacopa monnieri extract increases rat coronary flow and protects against myocardial ischemia/reperfusion injury.Modulation of p38 kinase by DUSP4 is important in regulating cardiovascular function under oxidative stressDisruption of TAB1/p38α interaction using a cell-permeable peptide limits myocardial ischemia/reperfusion injury.Role of PTEN in modulation of ADP-dependent signaling pathways in vascular endothelial cells.Developing small molecules to inhibit kinases unkind to the heart: p38 MAPK as a case in point.Role of p38 inhibition in cardiac ischemia/reperfusion injury.Therapeutic potential of p38 MAP kinase inhibition in the management of cardiovascular disease.The activation of p38 alpha, and not p38 beta, mitogen-activated protein kinase is required for ischemic preconditioning.Effect of pressure overload-induced hypertrophy on the expression and localization of p38 MAP kinase isoforms in the mouse heart.Inhibition of p38 MAPK activation protects cardiac mitochondria from ischemia/reperfusion injury.TAB1-induced auto-activation of p38α mitogen-activated protein kinase is crucially dependent on Threonine 185.The cardioprotective effects of secretory leukocyte protease inhibitor against myocardial ischemia/reperfusion injury.The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules
P2860
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P2860
A chemical genetic approach reveals that p38alpha MAPK activation by diphosphorylation aggravates myocardial infarction and is prevented by the direct binding of SB203580.
description
2009 nî lūn-bûn
@nan
2009年の論文
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2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
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2009年论文
@wuu
2009年论文
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2009年论文
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name
A chemical genetic approach re ...... he direct binding of SB203580.
@en
type
label
A chemical genetic approach re ...... he direct binding of SB203580.
@en
prefLabel
A chemical genetic approach re ...... he direct binding of SB203580.
@en
P2093
P2860
P50
P356
P1476
A chemical genetic approach re ...... the direct binding of SB203580
@en
P2093
Rekha Bassi
Sarawut Kumphune
Sebastien Jacquet
Sharwari Verma
Stephen J O'Keefe
P2860
P304
P356
10.1074/JBC.M109.079228
P407
P577
2009-12-07T00:00:00Z