A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants - Wikidata - awgldk - TriplyDB

A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants

A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants

http://www.wikidata.org/entity/Q41817504

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Opposing action of casein kinase 1 and calcineurin in nucleo-cytoplasmic shuttling of mammalian translation initiation factor eIF6 Neutral sphingomyelinase 2 (nSMase2) is a phosphoprotein regulated by calcineurin (PP2B)Therapeutic strategies for anchored kinases and phosphatases: exploiting short linear motifs and intrinsic disorder The Molecular Mechanism of Substrate Engagement and Immunosuppressant Inhibition of Calcineurin mTOR kinase structure, mechanism and regulation Psy2 targets the PP4 family phosphatase Pph3 to dephosphorylate Mth1 and repress glucose transporter gene expression.Regulation of the phosphatase PP2B by protein-protein interactions Insights on neoplastic stem cells from gel-based proteomics of childhood germ cell tumors A calcineurin docking motif (LXVP) in dynamin-related protein 1 contributes to mitochondrial fragmentation and ischemic neuronal injury.The calcineurin signaling network evolves via conserved kinase-phosphatase modules that transcend substrate identity The LQLP calcineurin docking site is a major determinant of the calcium-dependent activation of human TRESK background K+ channel.Two heterozygous mutations in NFATC1 in a patient with Tricuspid Atresia.Acidic calcium stores of Saccharomyces cerevisiae.Calcium channel blockers act through nuclear factor Y to control transcription of key cardiac genes.Novel motif in calcineurin catalytic subunit is required for septal localization of calcineurin in Aspergillus fumigatus Cooperative autoinhibition and multi-level activation mechanisms of calcineurin Quercetin targets the interaction of calcineurin with LxVP-type motifs in immunosuppression.Investigating the human Calcineurin Interaction Network using the πɸLxVP SLiM.IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact.Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506?Interaction of calcineurin with substrates and targeting proteins.Functional diversity and pharmacological profiles of the FKBPs and their complexes with small natural ligands.Regulator of calcineurin 1 mediates pathological vascular wall remodeling The CRaZy Calcium Cycle.Specific calcineurin targeting in macrophages confers resistance to inflammation via MKP-1 and p38 Calcineurin signaling in the heart: The importance of time and place.NFATc1/αA: The other Face of NFAT Factors in Lymphocytes.C/EBPβ and Nuclear Factor of Activated T Cells Differentially Regulate Adamts-1 Induction by Stimuli Associated with Vascular Remodeling.Strategies to make protein serine/threonine (PP1, calcineurin) and tyrosine phosphatases (PTP1B) druggable: achieving specificity by targeting substrate and regulatory protein interaction sites.The LxVP and PxIxIT NFAT motifs bind jointly to overlapping epitopes on calcineurin's catalytic domain distant to the regulatory domain.Precision attack on calcineurin in macrophages: a new anti-inflammatory weapon.Hph1 and Hph2 are novel components of the Sec63/Sec62 posttranslational translocation complex that aid in vacuolar proton ATPase biogenesis.The Ca2+/calcineurin-dependent signaling pathway in the gray mold Botrytis cinerea: the role of calcipressin in modulating calcineurin activity.The unique C terminus of the calcineurin isoform CNAβ1 confers non-canonical regulation of enzyme activity by Ca2+ and calmodulin.Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity Genetic bypass of Aspergillus nidulans crzA function in calcium homeostasis.Phospho-regulation and nucleocytoplasmic trafficking of CrzA in response to calcium and alkaline-pH stress in Aspergillus nidulans.Peptides derived from transcription factor EB bind to calcineurin at a similar region as the NFAT-type motif.Identification of small-molecule inhibitors of calcineurin-NFATc signaling that mimic the PxIxIT motif of calcineurin binding partners.Kisspeptin/GPR54 signaling restricts antiviral innate immune response through regulating calcineurin phosphatase activity

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A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants

http://www.wikidata.org/entity/Q41817504

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A conserved docking surface on ...... strates and immunosuppressants

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Antonio Pineda-Lucena

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Antonio Rodríguez

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David Pantoja-Uceda

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Jagoree Roy

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Juan Miguel Redondo

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Leticia Ortí

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María Dolores López-Maderuelo

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Perla Niño-Moreno

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Sara Martínez-Martínez

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P2860

Two cytoplasmic candidates for immunophilin action are revealed by affinity for a new cyclophilin: one in the presence and one in the absence of CsA

Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex

Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes

Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin

Characterization of the interaction between DARPP-32 and protein phosphatase 1 (PP-1): DARPP-32 peptides antagonize the interaction of PP-1 with binding proteins

Structure of calcineurin in complex with PVIVIT peptide: portrait of a low-affinity signalling interaction

X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

Calcineurin acts through the CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast

Hph1p and Hph2p, novel components of calcineurin-mediated stress responses in Saccharomyces cerevisiae.

A conserved family of calcineurin regulators.

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24200540

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immunosuppression

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