Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements.
about
Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancerTDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damageThe genomic complexity of primary human prostate cancerChoreographing the Double Strand Break Response: Ubiquitin and SUMO Control of Nuclear ArchitectureRecurrent rearrangements in prostate cancer: causes and therapeutic potentialThe mutational landscape of prostate cancerBiologic and clinical significance of androgen receptor variants in castration resistant prostate cancerDrugging topoisomerases: lessons and challengesThe convergence of DNA damage checkpoint pathways and androgen receptor signaling in prostate cancerInterplay between genomic alterations and androgen receptor signaling during prostate cancer development and progressionTDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivoStructural basis of type II topoisomerase inhibition by the anticancer drug etoposideThe Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA CleavageStructural basis for recognition of 5′-phosphotyrosine adducts by Tdp2TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural functionNBN gain is predictive for adverse outcome following image-guided radiotherapy for localized prostate cancerNovel non-AR therapeutic targets in castrate resistant prostate cancerCheckpoint Kinase 2 Negatively Regulates Androgen Sensitivity and Prostate Cancer Cell Growth.ERG is a critical regulator of Wnt/LEF1 signaling in prostate cancerPrognostic outlier genes for enhanced prostate cancer treatment.Targeting DNA repair with combination veliparib (ABT-888) and temozolomide in patients with metastatic castration-resistant prostate cancerAndrogen regulation of the TMPRSS2 gene and the effect of a SNP in an androgen response elementInfluence of oncogenic transcription factors on chromatin conformation and implications in prostate cancer.Chem-seq permits identification of genomic targets of drugs against androgen receptor regulation selected by functional phenotypic screens.Wnt signaling pathway protein LEF1 in cancer, as a biomarker for prognosis and a target for treatment.Chromosome-wide mapping of DNA methylation patterns in normal and malignant prostate cells reveals pervasive methylation of gene-associated and conserved intergenic sequencesBipolar androgen therapy: the rationale for rapid cycling of supraphysiologic androgen/ablation in men with castration resistant prostate cancer.Molecular genetics of prostate cancer: new prospects for old challengesMolecular pathways: targeting ETS gene fusions in cancer.RNA-Seq mapping and detection of gene fusions with a suffix array algorithm.Genomic hypomethylation in the human germline associates with selective structural mutability in the human genome.Resistance emerges to second-generation antiandrogens in prostate cancer.Human α(2)β(1)(HI) CD133(+VE) epithelial prostate stem cells express low levels of active androgen receptorActivity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response GenesClonal progression of prostate cancers from Gleason grade 3 to grade 4.Inactivation of ATM/ATR DNA damage checkpoint promotes androgen induced chromosomal instability in prostate epithelial cellsControlled DNA "damage" and repair in hypoxic signalingInvolvement of different mechanisms for the association of CAG repeat length polymorphism in androgen receptor gene with prostate cancerGenomic rearrangements in prostate cancer.Alterations in nucleolar structure and gene expression programs in prostatic neoplasia are driven by the MYC oncogene.
P2860
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P2860
Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Androgen-induced TOP2B-mediate ...... te cancer gene rearrangements.
@en
type
label
Androgen-induced TOP2B-mediate ...... te cancer gene rearrangements.
@en
prefLabel
Androgen-induced TOP2B-mediate ...... te cancer gene rearrangements.
@en
P2093
P2860
P356
P1433
P1476
Androgen-induced TOP2B-mediate ...... te cancer gene rearrangements.
@en
P2093
Alan K Meeker
Angelo M De Marzo
Antoun Toubaji
Bora Gurel
David M Esopi
G Steven Bova
George Netto
Martin J Aryee
Michael C Haffner
Roula Albadine
P2860
P2888
P304
P356
10.1038/NG.613
P407
P50
P577
2010-07-04T00:00:00Z
P5875
P6179
1017624697