Effect of PI3K- and mTOR-specific inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKB1-deficient mice - Wikidata - awgldk - TriplyDB

Effect of PI3K- and mTOR-specific inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKB1-deficient mice

Effect of PI3K- and mTOR-specific inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKB1-deficient mice

http://www.wikidata.org/entity/Q41826974

about

Targeting the phosphoinositide 3-kinase pathway in hematologic malignancies Puquitinib, a novel orally available PI3Kδ inhibitor, exhibits potent antitumor efficacy against acute myeloid leukemia Clinical development of phosphatidylinositol 3-kinase inhibitors for cancer treatment Loss of LKB1 expression reduces the latency of ErbB2-mediated mammary gland tumorigenesis, promoting changes in metabolic pathways Pre-clinical study of drug combinations that reduce breast cancer burden due to aberrant mTOR and metabolism promoted by LKB1 loss.Quantitative MRI establishes the efficacy of PI3K inhibitor (GDC-0941) multi-treatments in PTEN-deficient mice lymphoma The Expression of CD9 and PIK3CD is Associated with Prognosis of Follicular Lymphoma.Targeting the Mammalian Target of Rapamycin (mTOR) in Cancer Therapy: Lessons from Past and Future Perspectives Phosphatidylinositol 3-kinase (PI3K) inhibitors as cancer therapeutics.mTOR pathway in colorectal cancer: an update.PI3K and Akt as molecular targets for cancer therapy: current clinical outcomes.CAL-101: a phosphatidylinositol-3-kinase p110-delta inhibitor for the treatment of lymphoid malignancies.Signaling pathways in lymphoma: pathogenesis and therapeutic targets.Isotype-specific inhibition of the phosphatidylinositol-3-kinase pathway in hematologic malignancies.Dissecting the signaling pathways that mediate cancer in PTEN and LKB1 double-knockout mice.Novel agents in indolent lymphomas.Involvement of the Syk-mTOR pathway in follicular lymphoma cell invasion and angiogenesis.Loperamide Restricts Intracellular Growth of Mycobacterium tuberculosis in Lung Macrophages.PI3Kδ-selective and PI3Kα/δ-combinatorial inhibitors in clinical development for B-cell non-Hodgkin lymphoma.Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice.Selective inhibitors of phosphoinositide 3-kinase delta: modulators of B-cell function with potential for treating autoimmune inflammatory diseases and B-cell malignancies.Expression of Spy1 protein in human non-Hodgkin's lymphomas is correlated with phosphorylation of p27 Kip1 on Thr187 and cell proliferation.Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy.

P2860

Q33558141-756151A1-C17A-4D11-B616-392C11D2E28C Q33873323-11D097C5-7000-4ACB-934B-C820DE4D17C1 Q34508976-B87B98DA-62AA-47F6-9635-CB625AE1DC0B Q34602408-D307F654-3361-4336-97A4-9DDCC183ACEC Q35149656-6421DF30-D479-4E9D-9495-5D57C6D28F70 Q35799358-451CA3D8-6F9B-41CF-9AA3-E8C8E645985B Q36214120-97FB2DD3-F036-48AF-A09D-F76ADD01FCC0 Q37132788-8B864038-DE47-45E7-988E-8E82C5A38D59 Q37350230-D3100813-10AA-4615-A52C-3F0271902381 Q37649634-2B48331D-711B-4602-8FDA-18B115EC9D76 Q37727180-94CBBCF3-6A2B-46DB-8F69-2166C16AA705 Q37960157-D7E8B566-4685-416A-A873-BF660EEB4B4C Q38150876-F37D7EF5-5503-4039-91A4-C494CA070AC2 Q38193070-2D572AFA-67DB-4DBE-A52E-825B385A5032 Q38578489-74CC3985-B542-43E4-9891-32ED9F5DC149 Q39431412-F76F99C6-D0F9-4F19-9DC8-805987D5F526 Q39472188-EC746E96-2B99-43F8-87A4-5F74D877F580 Q40596664-949996BE-3ACE-40EF-B8A8-B31479CEB07C Q41994564-954B7261-E73C-4380-9179-C61E7B92C0FC Q42135510-758FE85A-6A44-48AD-AE79-1558B6507367 Q42320922-F27464DD-2241-4883-A7BC-3523BC3139E0 Q54518212-C536F4B8-985E-4E11-9CD5-2ED35ED1709D Q54978251-3E512E2D-4FC3-4A99-B4F4-3596B7F09B24

P2860

Effect of PI3K- and mTOR-specific inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKB1-deficient mice

http://www.wikidata.org/entity/Q41826974

description

2011 nî lūn-bûn

@nan

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

2011年论文

@zh

2011年论文

@zh-cn

name

Effect of PI3K- and mTOR-speci ...... as in PTEN/LKB1-deficient mice

@en

type

label

Effect of PI3K- and mTOR-speci ...... as in PTEN/LKB1-deficient mice

@en

prefLabel

Effect of PI3K- and mTOR-speci ...... as in PTEN/LKB1-deficient mice

@en

P1433

Q41826974-38366585-DEB4-4F61-BFEE-9FD419EB1E27

P1476

Q41826974-CF2C7733-9B7B-4C5D-BB27-9381CBA21387

P2093

Q41826974-7081A20A-8710-4FA9-8902-54FCFD5F83A1

Q41826974-7681EE32-9126-4565-BA2C-A5B87EF3BD87

Q41826974-8D3812BB-7931-4D75-A85A-55106C26ED39

Q41826974-91651C40-82BE-4E83-BAF3-7E905E8D83A0

Q41826974-A4CEED0A-62DA-49F6-829B-7B4FF0C2C8D9

Q41826974-B2FBCC14-D443-4E4E-A9E9-5C2067A64E6A

Q41826974-E5E9A46D-E023-43B1-BD26-1AE405059D27

P2860

Q41826974-08CA78B9-B8E0-47A3-A0D8-3006EEACA867

Q41826974-10602C4E-2031-40AC-A43A-0F9892054047

Q41826974-1426F87C-3A65-4216-85C1-F8BD01E91A71

Q41826974-145781B0-3164-4449-842A-3D9E69950394

Q41826974-16022B4E-76B9-42D8-B3B8-715DAEF3B5C9

Q41826974-17B53E1E-BBE3-45B0-9DF6-131E6493F1F3

Q41826974-1E702FF0-4320-4A59-BF6B-512D82A14397

Q41826974-24C23E72-77C0-46D5-A482-7EF5333EFBE7

Q41826974-280CF6E6-B73A-4F42-8191-E6D79FDAA93F

Q41826974-3AE81A5F-483B-4513-9FE7-7D108CEBA462

P2888

Q41826974-FCFC1FA4-D7BF-4A5E-AA66-8030DCC63225

P304

Q41826974-093328E4-CA75-4D08-AE28-0FF99134A6DE

P31

Q41826974-3D1C2904-1175-434D-B5F7-CBF6F08FB594

P356

Q41826974-8E6358B0-A3CA-4980-9287-1BD7A6A58966

P407

Q41826974-EECB1483-E8F4-43F0-8799-9BBA1E990C84

P433

Q41826974-F39C376C-05C1-4E75-9539-7BB242649836

P478

Q41826974-3DD2F9B2-E6E7-4C01-B365-AB97CC45FFAE

P577

Q41826974-A325679A-2BA7-4AE8-B71E-FDE38FAAEFC7

P5875

Q41826974-42915B2A-7D1B-4515-9718-332AFD81A9FF

P6179

Q41826974-832E1CA4-DB41-4363-A960-89B933BA577A

P698

Q41826974-062271BA-8CBE-49C0-9739-198FAB4D7989

P932

Q41826974-BD3FFBAE-D453-49F6-B7B7-6D851BBDBFB4

P356

P1433

British Journal of Cancer

P1476

Effect of PI3K- and mTOR-speci ...... as in PTEN/LKB1-deficient mice

@en

P2093

D R Alessi

http://www.w3.org/2001/XMLSchema#string

G Preston

http://www.w3.org/2001/XMLSchema#string

J M García-Martínez

http://www.w3.org/2001/XMLSchema#string

S Fleming

http://www.w3.org/2001/XMLSchema#string

S Guichard

http://www.w3.org/2001/XMLSchema#string

S L Duce

http://www.w3.org/2001/XMLSchema#string

S Wullschleger

http://www.w3.org/2001/XMLSchema#string

P2860

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

PTEN function: how normal cells control it and tumour cells lose it

Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3

mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice

The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.

TOR signaling in growth and metabolism

High frequency of mutations of the PIK3CA gene in human cancers

P2888

P304

1116-1125

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/BJC.2011.83

http://www.w3.org/2001/XMLSchema#string

P407

P433

7

http://www.w3.org/2001/XMLSchema#string

P478

104

http://www.w3.org/2001/XMLSchema#string

P577

2011-03-15T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

50399210

http://www.w3.org/2001/XMLSchema#string

P6179

1052328923

http://www.w3.org/2001/XMLSchema#string

P698

21407213

http://www.w3.org/2001/XMLSchema#string

P932

3068512

http://www.w3.org/2001/XMLSchema#string