Characterization of des-(741-1668)-factor VIII, a single-chain factor VIII variant with a fusion site susceptible to proteolysis by thrombin and factor Xa.
about
Structural investigation of zymogenic and activated forms of human blood coagulation factor VIII: a computational molecular dynamics studyRemoval of B-domain sequences from factor V rather than specific proteolysis underlies the mechanism by which cofactor function is realized.Intracellular retention of a factor VIII protein with an Arg2307-->Gln mutation as a cause of haemophilia A.Substitution of Arg527 and Arg531 in factor VIII associated with mild haemophilia A: characterization in terms of subunit interaction and cofactor function.Intracellular accumulation of factor VIII induced by missense mutations Arg593-->Cys and Asn618-->Ser explains cross-reacting material-reduced haemophilia A.Evaluation of the haemostatic potential of factor VIII-heparin cofactor II hybrid proteins in a mouse model.An antibody specific for coagulation factor IX enhances the activity of the intrinsic factor X-activating complex.Some factor VIII exon 14 frameshift mutations cause moderately severe haemophilia A.
P2860
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P2860
Characterization of des-(741-1668)-factor VIII, a single-chain factor VIII variant with a fusion site susceptible to proteolysis by thrombin and factor Xa.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Characterization of des-(741-1 ...... sis by thrombin and factor Xa.
@en
type
label
Characterization of des-(741-1 ...... sis by thrombin and factor Xa.
@en
prefLabel
Characterization of des-(741-1 ...... sis by thrombin and factor Xa.
@en
P2093
P2860
P356
P1433
P1476
Characterization of des-(741-1 ...... sis by thrombin and factor Xa.
@en
P2093
Biessels PT
Lenting PJ
Voorberg J
de Laaf RT
van Mourik JA
van de Loo JW
P2860
P356
10.1042/BJ3120049
P407
P478
312 ( Pt 1)
P577
1995-11-01T00:00:00Z