Isolation and characterization of human factor VIII: molecular forms in commercial factor VIII concentrate, cryoprecipitate, and plasma.
about
Secretion of coagulant factor VIII activity and antigen by in vitro cultivated rat liver sinusoidal endothelial cellsDefining 'full-length' recombinant factor VIII: a comparative structural analysis.Purification and characterization of a new recombinant factor VIII (N8).Epitope mapping of human factor VIII inhibitor antibodies by deletion analysis of factor VIII fragments expressed in Escherichia coli.Protein replacement therapy and gene transfer in canine models of hemophilia A, hemophilia B, von willebrand disease, and factor VII deficiency.Factor VIII light chain contains a binding site for factor X that contributes to the catalytic efficiency of factor Xase.Variable contributions of basic residues forming an APC exosite in the binding and inactivation of factor VIIIaNovel factor VIII variants with a modified furin cleavage site improve the efficacy of gene therapy for hemophilia A.The sequence Glu1811-Lys1818 of human blood coagulation factor VIII comprises a binding site for activated factor IX.A critical appraisal of one-stage and chromogenic assays of factor VIII activity.Molecular design and downstream processing of turoctocog alfa (NovoEight), a B-domain truncated factor VIII molecule.Intracellular retention of a factor VIII protein with an Arg2307-->Gln mutation as a cause of haemophilia A.Inhibition of human coagulation factor VIII by monoclonal antibodies. Mapping of functional epitopes with the use of recombinant factor VIII fragments.Structural and functional characterization of Factor VIII-delta II, a new recombinant Factor VIII lacking most of the B-domain.The pro-polypeptide of von Willebrand factor is required for the formation of a functional factor VIII-binding site on mature von Willebrand factor.The interaction between human blood-coagulation factor VIII and von Willebrand factor. Characterization of a high-affinity binding site on factor VIII.Characterization of des-(741-1668)-factor VIII, a single-chain factor VIII variant with a fusion site susceptible to proteolysis by thrombin and factor Xa.Binding of blood coagulation factor VIII and its light chain to phosphatidylserine/phosphatidylcholine bilayers as measured by ellipsometry.pH-dependent association of factor VIII chains: enhancement of affinity at physiological pH by Cu2+.Dissimilar interaction of factor VIII with endothelial cells and lipid vesicles during factor X activation.Factor VIII polypeptide specificity of monoclonal anti-factor VIII antibodies.Residues 110-126 in the A1 domain of factor VIII contain a Ca2+ binding site required for cofactor activity.Assay of factor VIII antigen (VIII:CAg) in 294 haemophilia A patients by a new commercial ELISA using monoclonal antibodies.Intracellular accumulation of factor VIII induced by missense mutations Arg593-->Cys and Asn618-->Ser explains cross-reacting material-reduced haemophilia A.Structural analysis of the recombinant therapeutic product rFVIII and its PEGylated variants using 2-D DIGE.Biological activity of recombinant factor VIII variants lacking the central B-domain and the heavy-chain sequence Lys713-Arg740: discordant in vitro and in vivo activity.Proteolysis of factor VIII heavy chain polypeptides in plasma and concentrates.Factor VIII heavy chain polypeptides in plasma and concentrates.Monoclonal antibodies to factor VIII: their application in immunoblotting for the visualization of factor VIII in therapeutic concentrates and plasma.Deep sequencing reveals different compositions of mRNA transcribed from the F8 gene in a panel of FVIII-producing CHO cell lines.Contribution of factor VIII light-chain residues 2007-2016 to an activated protein C-interactive site.
P2860
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P2860
Isolation and characterization of human factor VIII: molecular forms in commercial factor VIII concentrate, cryoprecipitate, and plasma.
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
1986年论文
@zh
1986年论文
@zh-cn
name
Isolation and characterization ...... , cryoprecipitate, and plasma.
@ast
Isolation and characterization ...... , cryoprecipitate, and plasma.
@en
type
label
Isolation and characterization ...... , cryoprecipitate, and plasma.
@ast
Isolation and characterization ...... , cryoprecipitate, and plasma.
@en
prefLabel
Isolation and characterization ...... , cryoprecipitate, and plasma.
@ast
Isolation and characterization ...... , cryoprecipitate, and plasma.
@en
P2093
P2860
P356
P1476
Isolation and characterization ...... , cryoprecipitate, and plasma.
@en
P2093
Andersson LO
Sandberg H
P2860
P304
P356
10.1073/PNAS.83.9.2979
P407
P577
1986-05-01T00:00:00Z