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Posttranslationally processed structure of the human platelet protein smg p21B: evidence for geranylgeranylation and carboxyl methylation of the C-terminal cysteineNew targets for therapy in breast cancer: farnesyltransferase inhibitors.The farnesyl transferase inhibitor RPR-130401 does not alter radiation susceptibility in human tumor cells with a K-Ras mutation in spite of large changes in ploidy and lamin B distributionThe Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C-terminal methylation of a-factor and RAS proteins.RAM2, an essential gene of yeast, and RAM1 encode the two polypeptide components of the farnesyltransferase that prenylates a-factor and Ras proteins.Protein geranylgeranyltransferase of Saccharomyces cerevisiae is specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43 gene product but not the DPR1 gene productThe gamma subunit of transducin is farnesylatedFarnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivoThe nucleocytoplasmic continuum. Pushing the (nuclear) envelope.Targeting protein prenylation for cancer therapyBrain G protein gamma subunits contain an all-trans-geranylgeranylcysteine methyl ester at their carboxyl termini.G protein gamma subunits contain a 20-carbon isoprenoid.The posttranslational processing of prelamin A and disease.Prenylated proteins: synthesis of geranylgeranylcysteine and identification of this thioether amino acid as a component of proteins in CHO cells.Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins.Therapeutic intervention based on protein prenylation and associated modificationsCell cycle-specific effects of lovastatin.Structural analysis of protein prenyl groups and associated C-terminal modificationsCigarette smoke-induced pulmonary inflammatory responses are mediated by EGR-1/GGPPS/MAPK signaling.An early response transcription factor, Egr-1, enhances insulin resistance in type 2 diabetes with chronic hyperinsulinismProtein prenylation: enzymes, therapeutics, and biotechnology applications.RhoB prenylation is driven by the three carboxyl-terminal amino acids of the protein: evidenced in vivo by an anti-farnesyl cysteine antibody.GGPPS, a new EGR-1 target gene, reactivates ERK 1/2 signaling through increasing Ras prenylation.Colocalization of vertebrate lamin B and lamin B receptor (LBR) in nuclear envelopes and in LBR-induced membrane stacks of the yeast Saccharomyces cerevisiae.Disassembly of in vitro formed lamin head-to-tail polymers by CDC2 kinase.Synergism between a novel amphibian oocyte ribonuclease and lovastatin in inducing cytostatic and cytotoxic effects in human lung and pancreatic carcinoma cell lines.Biogenesis of the Saccharomyces cerevisiae pheromone a-factor, from yeast mating to human disease.Phosphorylation on protein kinase C sites inhibits nuclear import of lamin B2.The CaaX motif is required for isoprenylation, carboxyl methylation, and nuclear membrane association of lamin B2.Regulation of intracellular actin polymerization by prenylated cellular proteins.Farnesyl cysteine C-terminal methyltransferase activity is dependent upon the STE14 gene product in Saccharomyces cerevisiae.v-K-ras leads to preferential farnesylation of p21(ras) in FRTL-5 cells: multiple interference with the isoprenoid pathway.Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein.Nucleoplasmic localization of prelamin A: implications for prenylation-dependent lamin A assembly into the nuclear laminaEndoproteolytic processing of a farnesylated peptide in vitro.Selective cleavage of thioether linkage in proteins modified with 4-hydroxynonenal.Novel route to chaetomellic acid A and analogues: serendipitous discovery of a more competent FTase inhibitor.Farnesyltransferase inhibitor R115777 inhibits cell growth and induces apoptosis in mantle cell lymphoma.Covalent modification of proteins by ligands of steroid hormone receptorsIncreasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome.
P2860
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P2860
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
1989年论文
@zh
1989年论文
@zh-cn
name
Human lamin B contains a farnesylated cysteine residue
@en
type
label
Human lamin B contains a farnesylated cysteine residue
@en
prefLabel
Human lamin B contains a farnesylated cysteine residue
@en
P2093
P2860
P1476
Human lamin B contains a farnesylated cysteine residue
@en
P2093
C C Farnsworth
J A Glomset
P2860
P304
20422-20429
P407
P577
1989-12-01T00:00:00Z