The Nef protein of human immunodeficiency virus is a broad-spectrum modulator of chemokine receptor cell surface levels that acts independently of classical motifs for receptor endocytosis and Galphai signaling.

The Nef protein of human immunodeficiency virus is a broad-spectrum modulator of chemokine receptor cell surface levels that acts independently of classical motifs for receptor endocytosis and Galphai signaling.

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http://www.wikidata.org/entity/Q41849313
One protein to rule them all: modulation of cell surface receptors and molecules by HIV Nef.Human immunodeficiency virus type 1 envelope gp120 induces a stop signal and virological synapse formation in noninfected CD4+ T cells.HIV-1 Nef employs two distinct mechanisms to modulate Lck subcellular localization and TCR induced actin remodeling.Molecular Mechanisms of Neurodegenerative Diseases Induced by Human Retroviruses: A Review.Host factors determine differential disease progression after infection with nef-deleted simian immunodeficiency virusCommitment to apoptosis in CD4(+) T lymphocytes productively infected with human immunodeficiency virus type 1 is initiated by lysosomal membrane permeabilization, itself induced by the isolated expression of the viral protein NefHIV-1 Nef impairs heterotrimeric G-protein signaling by targeting Gα(i2) for degradation through ubiquitination.Viral modulation of T-cell receptor signalingHIV-1 Nef down-modulates C-C and C-X-C chemokine receptors via ubiquitin and ubiquitin-independent mechanismHIV-1 Nef: Taking Control of Protein Trafficking.HIV-1 Nef and Vpu are functionally redundant broad-spectrum modulators of cell surface receptors, including tetraspanins.SDF-1/CXCL12 production by mature dendritic cells inhibits the propagation of X4-tropic HIV-1 isolates at the dendritic cell-T-cell infectious synapse.Expression of Nef downregulates CXCR4, the major coreceptor of human immunodeficiency virus, from the surfaces of target cells and thereby enhances resistance to superinfection.Lentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling.Design and in vitro characterization of highly sst2-selective somatostatin antagonists suitable for radiotargeting.Human immunodeficiency virus type 1 Nef incorporation into virions does not increase infectivityIdentification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function
P2860

The Nef protein of human immunodeficiency virus is a broad-spectrum modulator of chemokine receptor cell surface levels that acts independently of classical motifs for receptor endocytosis and Galphai signaling.

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http://www.wikidata.org/entity/Q41849313
description
2006 nî lūn-bûn
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The Nef protein of human immun ...... cytosis and Galphai signaling.
@en
type
label
The Nef protein of human immun ...... cytosis and Galphai signaling.
@en
prefLabel
The Nef protein of human immun ...... cytosis and Galphai signaling.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P698
P932
P356
P1433
P1476
The Nef protein of human immun ...... cytosis and Galphai signaling.
@en
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P698
P932