HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes - Wikidata - awgldk - TriplyDB

HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes

HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes

http://www.wikidata.org/entity/Q22253302

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HIV-1 Nef impairs MHC class II antigen presentation and surface expression Mechanism for down-regulation of CD28 by Nef.CLIPR-59, a new trans-Golgi/TGN cytoplasmic linker protein belonging to the CLIP-170 family A PACS-1, GGA3 and CK2 complex regulates CI-MPR trafficking Direct binding of human immunodeficiency virus type 1 Nef to the major histocompatibility complex class I (MHC-I) cytoplasmic tail disrupts MHC-I trafficking Structure--function relationships in HIV-1 Nef.Subunit H of the V-ATPase involved in endocytosis shows homology to beta-adaptins PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic.Autoantigen Golgin-97, an effector of Arl1 GTPase, participates in traffic from the endosome to the trans-golgi network The phosphorylation state of an autoregulatory domain controls PACS-1-directed protein traffic Furin at the cutting edge: from protein traffic to embryogenesis and disease Remodeling of the Host Cell Plasma Membrane by HIV-1 Nef and Vpu: A Strategy to Ensure Viral Fitness and Persistence Where in the Cell Are You? Probing HIV-1 Host Interactions through Advanced Imaging Techniques HSP72 inhibits apoptosis-inducing factor release in ATP-depleted renal epithelial cells Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef The AP2 binding site of synaptotagmin 1 is not an internalization signal but a regulator of endocytosis A hydrophobic binding surface on the human immunodeficiency virus type 1 Nef core is critical for association with p21-activated kinase 2.Single-domain antibody-SH3 fusions for efficient neutralization of HIV-1 Nef functions Structure, dynamics, and Hck interaction of full-length HIV-1 Nef.The HIV-1 Nef protein as a target for antiretroviral therapy.Design and use of an inducibly activated human immunodeficiency virus type 1 Nef to study immune modulation.Human immunodeficiency virus type 1 Nef associates with lipid rafts to downmodulate cell surface CD4 and class I major histocompatibility complex expression and to increase viral infectivity.HIV-1 Nef employs two distinct mechanisms to modulate Lck subcellular localization and TCR induced actin remodeling.HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells.An MHC-I cytoplasmic domain/HIV-1 Nef fusion protein binds directly to the mu subunit of the AP-1 endosomal coat complex.Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action Genetic characterization of HIV type 1 Nef-induced vesicle secretion Human immunodeficiency virus-1 Nef expression induces intracellular accumulation of multivesicular bodies and major histocompatibility complex class II complexes: potential role of phosphatidylinositol 3-kinase High viremia is associated with high levels of in vivo major histocompatibility complex class I Downregulation in rhesus macaques infected with simian immunodeficiency virus SIVmac239.Genetic and functional diversity of human immunodeficiency virus type 1 subtype B Nef primary isolates Nef from human immunodeficiency virus type 1(F12) inhibits viral production and infectivity Nef-induced CD4 downregulation: a diacidic sequence in human immunodeficiency virus type 1 Nef does not function as a protein sorting motif through direct binding to beta-COP.Intracellular trafficking of the UL11 tegument protein of herpes simplex virus type 1.Membrane targeting properties of a herpesvirus tegument protein-retrovirus Gag chimera.HIV-1 Nef down-regulates the hemochromatosis protein HFE, manipulating cellular iron homeostasis Nef proteins from diverse groups of primate lentiviruses downmodulate CXCR4 to inhibit migration to the chemokine stromal derived factor 1.HSP72 attenuates renal tubular cell apoptosis and interstitial fibrosis in obstructive nephropathy.Cell surface expression of the HIV-1 envelope glycoproteins is directed from intracellular CTLA-4-containing regulated secretory granules.HIV-1 Nef binds a subpopulation of MHC-I throughout its trafficking itinerary and down-regulates MHC-I by perturbing both anterograde and retrograde trafficking.

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P2860

HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes

http://www.wikidata.org/entity/Q22253302

description

2000 nî lūn-bûn

@nan

2000 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի մարտին հրատարակված գիտական հոդված

@hy

2000年の論文

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2000年論文

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2000年論文

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2000年論文

@zh-hk

2000年論文

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2000年論文

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2000年论文

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name

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Nature Cell Biology

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A Mangasarian

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P2860

Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes

Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4

Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation

Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes.

Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity

PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization

A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor

A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4

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2579363

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10.1038/35004038

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3

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1033605580

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1475706

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