Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins.
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Phosphoinositides: tiny lipids with giant impact on cell regulationG-protein-coupled receptor agonists activate endogenous phospholipase Cepsilon and phospholipase Cbeta3 in a temporally distinct mannerPhospholipase C epsilon scaffolds to muscle-specific A kinase anchoring protein (mAKAPbeta) and integrates multiple hypertrophic stimuli in cardiac myocytesPAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiologyClinical significance of the correlation between PLCE 1 and PRKCA in esophageal inflammation and esophageal carcinoma.PLCε mediated sustained signaling pathways.Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of LangerhansRole of phospholipase Cε in physiological phosphoinositide signaling networks.Phospholipase Cepsilon is a nexus for Rho and Rap-mediated G protein-coupled receptor-induced astrocyte proliferationThe Ras-like protein R-Ras2/TC21 is important for proper mammary gland development.G-protein signaling: back to the futurePhospholipase Cε Modulates Rap1 Activity and the Endothelial Barrier.Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 and Ras-associating domains of phospholipase CϵActivity of PLCε contributes to chemotaxis of fibroblasts towards PDGFPhospholipase C epsilon links G protein-coupled receptor activation to inflammatory astrocytic responses.Structure, functional regulation and signaling properties of Rap2B.Mechanism of activation and inactivation of Gq/phospholipase C-β signaling nodesRap2B promotes migration and invasion of human suprarenal epithelioma.Structural and spatial determinants regulating TC21 activation by RasGRF family nucleotide exchange factorsLysophosphatidic acid induces vasodilation mediated by LPA1 receptors, phospholipase C, and endothelial nitric oxide synthase.A sequence variant in the phospholipase C epsilon C2 domain is associated with esophageal carcinoma and esophagitis.The controversial role of phospholipase C epsilon (PLCε) in cancer development and progression.Revisited and revised: is RhoA always a villain in cardiac pathophysiology?Lysophospholipid receptor activation of RhoA and lipid signaling pathways.G12/13-dependent signaling of G-protein-coupled receptors: disease context and impact on drug discovery.PLCε signaling in cancer.β-Arrestin 1-dependent regulation of Rap2 is required for fMLP-stimulated chemotaxis in neutrophil-like HL-60 cells.Rap2B-dependent stimulation of phospholipase C-epsilon by epidermal growth factor receptor mediated by c-Src phosphorylation of RasGRP3.Phospholipase Cϵ Activates Nuclear Factor-κB Signaling by Causing Cytoplasmic Localization of Ribosomal S6 Kinase and Facilitating Its Phosphorylation of Inhibitor κB in Colon Epithelial Cells.Dual activation of phospholipase C-epsilon by Rho and Ras GTPasesPLCε1 regulates SDF-1α-induced lymphocyte adhesion and migration to sites of inflammation.p53 upregulates PLCε-IP3-Ca2+ pathway and inhibits autophagy through its target gene Rap2B.Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II.Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice.Phospholipase C isozymes as effectors of Ras superfamily GTPases.Ral signaling pathway in health and cancer.GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers.G protein βγ subunits directly interact with and activate phospholipase Cϵ.
P2860
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P2860
Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Hormonal regulation of phospho ...... G12 and Ras family G-proteins.
@en
type
label
Hormonal regulation of phospho ...... G12 and Ras family G-proteins.
@en
prefLabel
Hormonal regulation of phospho ...... G12 and Ras family G-proteins.
@en
P2093
P2860
P356
P1433
P1476
Hormonal regulation of phospho ...... G12 and Ras family G-proteins.
@en
P2093
Alan V Smrcka
Grant G Kelley
Sarah E Reks
P2860
P304
P356
10.1042/BJ20031370
P407
P577
2004-02-01T00:00:00Z