The general anesthetic propofol excites nociceptors by activating TRPV1 and TRPA1 rather than GABAA receptors
about
Transient receptor potential (TRP) channels as drug targets for diseases of the digestive systemDeciphering Subtype-Selective Modulations in TRPA1 Biosensor ChannelsSensitization of TRPA1 by Protein Kinase ATRPA1 and TRPV1 contribute to propofol-mediated antagonism of U46619-induced constriction in murine coronary arteries.The pain interactome: connecting pain-specific protein interactions.B-type natriuretic peptide-induced delayed modulation of TRPV1 and P2X3 receptors of mouse trigeminal sensory neurons.Propofol causes vasodilation in vivo via TRPA1 ion channels: role of nitric oxide and BKCa channelsReceptor specificity defines algogenic properties of propofol and fospropofol.The antinociceptive and antihyperalgesic effects of topical propofol on dorsal horn neurons in the rat.Paradoxic effects of propofol on visceral pain induced by various TRPV1 agonists.Targeting Pain-evoking Transient Receptor Potential Channels for the Treatment of Pain.Pain on propofol injection: Causes and remedies.CGRP and NO in the trigeminal system: mechanisms and role in headache generation.The transient receptor potential channel TRPA1: from gene to pathophysiology.New strategies to develop novel pain therapies: addressing thermoreceptors from different points of view.Sensory TRP channels: the key transducers of nociception and pain.Activation of TRPA1 by membrane permeable local anesthetics.The molecular basis for species-specific activation of human TRPA1 protein by protons involves poorly conserved residues within transmembrane domains 5 and 6.The Role of GABA Receptor Agonists in Anesthesia and Sedation.Sites Contributing to TRPA1 Activation by the Anesthetic Propofol Identified by Photoaffinity Labeling.The influence of propofol and sevoflurane on intestinal motility during laparoscopic surgery.Propofol-induced pain sensation involves multiple mechanisms in sensory neurons.Inhibition of acid-sensing ion channel currents by propofol in rat dorsal root ganglion neurons.Recent progress on the molecular pharmacology of propofol.Propacetamol-Induced Injection Pain Is Associated with Activation of Transient Receptor Potential Vanilloid 1 Channels.
P2860
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P2860
The general anesthetic propofol excites nociceptors by activating TRPV1 and TRPA1 rather than GABAA receptors
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
The general anesthetic propofo ...... A1 rather than GABAA receptors
@en
type
label
The general anesthetic propofo ...... A1 rather than GABAA receptors
@en
prefLabel
The general anesthetic propofo ...... A1 rather than GABAA receptors
@en
P2093
P2860
P356
P1476
The general anesthetic propofo ...... A1 rather than GABAA receptors
@en
P2093
Andreas Leffler
Florian Niedermirtl
Katrin Kistner
Michael J M Fischer
Mirjam Eberhardt
P2860
P304
34781-34792
P356
10.1074/JBC.M110.143958
P407
P577
2010-09-07T00:00:00Z