Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors - Wikidata - awgldk - TriplyDB

Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors

Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors

http://www.wikidata.org/entity/Q41875227

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Eph receptors and ephrin ligands: important players in angiogenesis and tumor angiogenesis Ligand targeting of EphA2 enhances keratinocyte adhesion and differentiation via desmoglein 1 Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex Guidance molecules in lung cancer The Role of Ephs and Ephrins in Memory Formation Targeting the Eph System with Peptides and Peptide Conjugates Eph/ephrin recognition and the role of Eph/ephrin clusters in signaling initiation Crystal Structure and NMR Binding Reveal That Two Small Molecule Antagonists Target the High Affinity Ephrin-binding Channel of the EphA4 Receptor Structural Plasticity of Eph Receptor A4 Facilitates Cross-Class Ephrin Signaling Structural Characterization of the EphA4-Ephrin-B2 Complex Reveals New Features Enabling Eph-Ephrin Binding Promiscuity Protein kinase A can block EphA2 receptor-mediated cell repulsion by increasing EphA2 S897 phosphorylation Lithocholic acid is an Eph-ephrin ligand interfering with Eph-kinase activation EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers Vascular endothelial growth factor (VEGF) and platelet (PF-4) factor 4 inputs modulate human microvascular endothelial signaling in a three-dimensional matrix migration context.Discovery and characterization of a novel cyclic peptide that effectively inhibits ephrin binding to the EphA4 receptor and displays anti-angiogenesis activity Binding of the Kaposi's sarcoma-associated herpesvirus to the ephrin binding surface of the EphA2 receptor and its inhibition by a small molecule.Ephrin-B3 supports glioblastoma growth by inhibiting apoptosis induced by the dependence receptor EphA4 High Expression of EphA4 Predicted Lesser Degree of Tumor Regression after Neoadjuvant Chemoradiotherapy in Rectal Cancer.Identification and characterization of Nanobodies targeting the EphA4 receptor.Engineering of monobody conjugates for human EphA2-specific optical imaging.Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease.Attenuation of scratch-induced reactive astrogliosis by novel EphA4 kinase inhibitors.Eph receptors and ephrins in cancer: bidirectional signalling and beyond.Protein dynamics at Eph receptor-ligand interfaces as revealed by crystallography, NMR and MD simulations.Resolving the paradox for protein aggregation diseases: NMR structure and dynamics of the membrane-embedded P56S-MSP causing ALS imply a common mechanism for aggregation-prone proteins to attack membranes High-content analysis of proapoptotic EphA4 dependence receptor functions using small-molecule libraries.Inhibition of Eph receptor-ephrin ligand interaction by tea polyphenols.A small molecule agonist of EphA2 receptor tyrosine kinase inhibits tumor cell migration in vitro and prostate cancer metastasis in vivo.Emerging strategies for EphA2 receptor targeting for cancer therapeutics.Eph receptor tyrosine kinases in cancer stem cells HTS by NMR of combinatorial libraries: a fragment-based approach to ligand discovery.Development and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptor EphA4 is a prognostic factor in gastric cancer.UniPR129 is a competitive small molecule Eph-ephrin antagonist blocking in vitro angiogenesis at low micromolar concentrations.Unique structure and dynamics of the EphA5 ligand binding domain mediate its binding specificity as revealed by X-ray crystallography, NMR and MD simulations Cortical abnormalities and non-spatial learning deficits in a mouse model of CranioFrontoNasal syndrome.EPHA2 is a mediator of vemurafenib resistance and a novel therapeutic target in melanoma.Eph receptors and ephrins as targets for cancer therapy.A disalicylic acid-furanyl derivative inhibits ephrin binding to a subset of Eph receptors High-Throughput Screening by Nuclear Magnetic Resonance (HTS by NMR) for the Identification of PPIs Antagonists

P2860

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P2860

Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors

http://www.wikidata.org/entity/Q41875227

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors

@en

type

label

Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors

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prefLabel

Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors

@en

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Journal of Biological Chemistry

P1476

Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors

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P2093

Elena B Pasquale

http://www.w3.org/2001/XMLSchema#string

Gregory P Roth

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Mitchell Koolpe

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Nicholas D P Cosford

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Russell Dahl

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Satyamaheshwar Peddibhotla

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Ying Su

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P2860

Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation

Blockade of EphA receptor tyrosine kinase activation inhibits vascular endothelial cell growth factor-induced angiogenesis.

Crystal structure of an Eph receptor-ephrin complex

Three-dimensional Structure of the EphB2 Receptor in Complex with an Antagonistic Peptide Reveals a Novel Mode of Inhibition

Crystal Structure and NMR Binding Reveal That Two Small Molecule Antagonists Target the High Affinity Ephrin-binding Channel of the EphA4 Receptor

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

A quantitative analysis of kinase inhibitor selectivity

Eph receptors in the adult brain

Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis

Bidirectional Eph-ephrin signaling during axon guidance

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29461-29472

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scholarly article

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10.1074/JBC.M804103200

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43

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P478

283

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Roberta Noberini

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2008-08-26T00:00:00Z

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18728010

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2570887

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