Augmented intrinsic activity of Factor VIIa by replacement of residues 305, 314, 337 and 374: evidence of two unique mutational mechanisms of activity enhancement.
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Mechanism of the Ca2+-induced Enhancement of the Intrinsic Factor VIIa ActivityDisulfide locked variants of factor VIIa with a restricted beta-strand conformation have enhanced enzymatic activityLong-term expression of canine FVIIa in hemophilic dogsAnalysis of factor VIIa binding to relipidated tissue factor by surface plasmon resonanceEnhancing human spermine synthase activity by engineered mutationsRecombinant factor VIIa analog NN1731 (V158D/E296V/M298Q-FVIIa) enhances fibrin formation, structure and stability in lipidated hemophilic plasma.Structural biology of factor VIIa/tissue factor initiated coagulationCatalytic domain modification and viral gene delivery of activated factor VII confers hemostasis at reduced expression levels and vector doses in vivo.Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa ActivityA combined structural dynamics approach identifies a putative switch in factor VIIa employed by tissue factor to initiate blood coagulation.Antibody-induced enhancement of factor VIIa activity through distinct allosteric pathways.Effect of recombinant factor VIIa variant (NN1731) on platelet function, clot structure and force onset time in whole blood from healthy volunteers and haemophilia patients.Factor VIIa analogue (V158D/E296V/M298Q-FVIIa) normalises clot formation in whole blood from patients with severe haemophilia A.The effects of 2-chloroprocaine on coagulation and fibrinolysis in the parturient: an in vitro study.The origins of enhanced activity in factor VIIa analogs and the interplay between key allosteric sites revealed by hydrogen exchange mass spectrometry.A loop of coagulation factor VIIa influencing macromolecular substrate specificity
P2860
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P2860
Augmented intrinsic activity of Factor VIIa by replacement of residues 305, 314, 337 and 374: evidence of two unique mutational mechanisms of activity enhancement.
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2004 nî lūn-bûn
@nan
2004年の論文
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2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Augmented intrinsic activity o ...... nisms of activity enhancement.
@en
type
label
Augmented intrinsic activity o ...... nisms of activity enhancement.
@en
prefLabel
Augmented intrinsic activity o ...... nisms of activity enhancement.
@en
P2093
P2860
P356
P1433
P1476
Augmented intrinsic activity o ...... nisms of activity enhancement.
@en
P2093
Anette Østergaard
Egon Persson
Ole H Olsen
P2860
P304
P356
10.1042/BJ20031596
P407
P577
2004-04-01T00:00:00Z