Crystal structures of uninhibited factor VIIa link its cofactor and substrate-assisted activation to specific interactions
about
Autoactivation of Thrombin PrecursorsDisulfide locked variants of factor VIIa with a restricted beta-strand conformation have enhanced enzymatic activityNatural and synthetic inhibitors of kallikrein-related peptidases (KLKs).Discovery methodology for the development of direct factor VIIa inhibitors.Kinetic dissection of the pre-existing conformational equilibrium in the trypsin fold.The structure of thrombin, a chameleon-like proteinase.Determinants of specificity in coagulation proteases.Histone H4 promotes prothrombin autoactivation.Activation mechanisms of coagulation factor IX.Proteases as therapeutics.Structural biology of factor VIIa/tissue factor initiated coagulationPhysiological fIXa activation involves a cooperative conformational rearrangement of the 99-loop.Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa ActivityAugmented intrinsic activity of Factor VIIa by replacement of residues 305, 314, 337 and 374: evidence of two unique mutational mechanisms of activity enhancement.A combined structural dynamics approach identifies a putative switch in factor VIIa employed by tissue factor to initiate blood coagulation.Sites involved in intra- and interdomain allostery associated with the activation of factor VIIa pinpointed by hydrogen-deuterium exchange and electron transfer dissociation mass spectrometry.The influence of residue 190 in the S1 site of trypsin-like serine proteases on substrate selectivity is universally conserved.Tissue factor activates allosteric networks in factor VIIa through structural and dynamic changes.High resolution structures of p-aminobenzamidine- and benzamidine-VIIa/soluble tissue factor: unpredicted conformation of the 192-193 peptide bond and mapping of Ca2+, Mg2+, Na+, and Zn2+ sites in factor VIIa.Molecular dissection of Na+ binding to thrombin.Evolutionary conservation of the allosteric activation of factor VIIa by tissue factor in lamprey.The missense Thr211Pro mutation in the factor X activation peptide of a bleeding patient causes molecular defect in the clotting cascade.Structural modulation of factor VIIa by full-length tissue factor (TF1-263): implication of novel interactions between EGF2 domain and TF.Interplay between conformational selection and zymogen activation.Severe FVII deficiency caused by a new point mutation combined with a previously undetected gene deletion
P2860
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P2860
Crystal structures of uninhibited factor VIIa link its cofactor and substrate-assisted activation to specific interactions
description
2002 nî lūn-bûn
@nan
2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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2002年の論文
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
@zh-my
2002年学术文章
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2002年學術文章
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name
Crystal structures of uninhibi ...... ation to specific interactions
@ast
Crystal structures of uninhibi ...... ation to specific interactions
@en
Crystal structures of uninhibi ...... ation to specific interactions
@nl
type
label
Crystal structures of uninhibi ...... ation to specific interactions
@ast
Crystal structures of uninhibi ...... ation to specific interactions
@en
Crystal structures of uninhibi ...... ation to specific interactions
@nl
prefLabel
Crystal structures of uninhibi ...... ation to specific interactions
@ast
Crystal structures of uninhibi ...... ation to specific interactions
@en
Crystal structures of uninhibi ...... ation to specific interactions
@nl
P2093
P50
P1476
Crystal structures of uninhibi ...... ation to specific interactions
@en
P2093
Allan D'Arcy
David W Banner
Erhard Kopetzki
Georg-Burkhard Kresse
Katrin Sichler
P304
P356
10.1016/S0022-2836(02)00747-7
P407
P577
2002-09-20T00:00:00Z