Initiation of base excision repair of oxidative lesions in nucleosomes by the human, bifunctional DNA glycosylase NTH1.
about
Accessing DNA damage in chromatin: Preparing the chromatin landscape for base excision repairNucleosome disruption by DNA ligase III-XRCC1 promotes efficient base excision repairMechanisms and Consequences of Double-Strand DNA Break Formation in ChromatinInsights into the glycosylase search for damage from single-molecule fluorescence microscopy.New insights in the removal of the hydantoins, oxidation product of pyrimidines, via the base excision and nucleotide incision repair pathways.Uracil DNA glycosylase activity on nucleosomal DNA depends on rotational orientation of targetsNon-specific DNA binding interferes with the efficient excision of oxidative lesions from chromatin by the human DNA glycosylase, NEIL1.Rotational dynamics of DNA on the nucleosome surface markedly impact accessibility to a DNA repair enzyme.Base excision repair: a critical player in many gamesNucleosomes suppress the formation of double-strand DNA breaks during attempted base excision repair of clustered oxidative damagesImpact of abasic site orientation within nucleosomes on human APE1 endonuclease activity.Activity of FEN1 endonuclease on nucleosome substrates is dependent upon DNA sequence but not flap orientationNovel method for site-specific induction of oxidative DNA damage reveals differences in recruitment of repair proteins to heterochromatin and euchromatinDNA damage response factors from diverse pathways, including DNA crosslink repair, mediate alternative end joining.Reduced Nuclease Activity of Apurinic/Apyrimidinic Endonuclease (APE1) Variants on Nucleosomes: IDENTIFICATION OF ACCESS RESIDUES.Expression and the Peculiar Enzymatic Behavior of the Trypanosoma cruzi NTH1 DNA GlycosylaseEfficient cleavage of single and clustered AP site lesions within mono-nucleosome templates by CHO-K1 nuclear extract contrasts with retardation of incision by purified APE1.Rules of engagement for base excision repair in chromatinFacilitation of base excision repair by chromatin remodeling.The structural location of DNA lesions in nucleosome core particles determines accessibility by base excision repair enzymesSite-specific Acetylation of Histone H3 Decreases Polymerase β Activity on Nucleosome Core Particles in VitroContribution of DNA unwrapping from histone octamers to the repair of oxidatively damaged DNA in nucleosomes.Base excision repair in chromatin: Insights from reconstituted systems.Design, synthesis, and characterization of nucleosomes containing site-specific DNA damageBase excision repair of oxidative DNA damage: from mechanism to disease.Unencumbered Pol β lyase activity in nucleosome core particles.G-quadruplex-forming promoter sequences enable transcriptional activation in response to oxidative stress.HMGB1 Stimulates Activity of Polymerase β on Nucleosome Substrates.Human cells contain a factor that facilitates the DNA glycosylase-mediated excision of oxidized bases from occluded sites in nucleosomes.The Human Ligase IIIα-XRCC1 Protein Complex Performs DNA Nick Repair after Transient Unwrapping of Nucleosomal DNA.Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer.Human OGG1 activity in nucleosomes is facilitated by transient unwrapping of DNA and is influenced by the local histone environment.
P2860
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P2860
Initiation of base excision repair of oxidative lesions in nucleosomes by the human, bifunctional DNA glycosylase NTH1.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Initiation of base excision re ...... nctional DNA glycosylase NTH1.
@en
type
label
Initiation of base excision re ...... nctional DNA glycosylase NTH1.
@en
prefLabel
Initiation of base excision re ...... nctional DNA glycosylase NTH1.
@en
P2093
P2860
P356
P1476
Initiation of base excision re ...... nctional DNA glycosylase NTH1.
@en
P2093
Amalthiya Prasad
David S Pederson
Susan S Wallace
P2860
P304
P356
10.1128/MCB.00791-07
P407
P577
2007-10-08T00:00:00Z