Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. - Wikidata - awgldk - TriplyDB

Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis.

Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis.

http://www.wikidata.org/entity/Q41888954

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ATM-mediated phosphorylation activates the tumor-suppressive function of B56γ-PP2A A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4 Protein Phosphatase 2A as a Therapeutic Target in Acute Myeloid Leukemia PP1 and PP2A phosphatases--cooperating partners in modulating retinoblastoma protein activation PPP2R5C Couples Hepatic Glucose and Lipid Homeostasis PP2A: The Achilles Heal in MDS with 5q Deletion Nuclear-cytoplasmic shuttling of Chibby controls beta-catenin signaling.Perspectives on the combination of radiotherapy and targeted therapy with DNA repair inhibitors in the treatment of pancreatic cancer The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease 14-3-3 proteins play a role in the cell cycle by shielding cdt2 from ubiquitin-mediated degradation Cell cycle checkpoint regulators reach a zillion.Distinct pools of cdc25C are phosphorylated on specific TP sites and differentially localized in human mitotic cells PP2A regulates the pro-apoptotic activity of FOXO1.Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta.A bifunctional regulatory element in human somatic Wee1 mediates cyclin A/Cdk2 binding and Crm1-dependent nuclear export.Evidence toward a dual phosphatase mechanism that restricts Aurora A (Thr-295) phosphorylation during the early embryonic cell cycle.Keratin 23, a novel DPC4/Smad4 target gene which binds 14-3-3ε.A B56gamma mutation in lung cancer disrupts the p53-dependent tumor-suppressor function of protein phosphatase 2A A critical review of the molecular pathophysiology of lenalidomide sensitivity in 5q - myelodysplastic syndromes.The expanding significance of keratin intermediate filaments in normal and diseased epithelia Isolation of human mitotic protein phosphatase complexes: identification of a complex between protein phosphatase 1 and the RNA helicase Ddx21.Identification of relevant cancer related-genes in the flat oyster Ostrea edulis affected by disseminated neoplasia.Keratin hypersumoylation alters filament dynamics and is a marker for human liver disease and keratin mutation.A tumor suppressor role for PP2A-B56alpha through negative regulation of c-Myc and other key oncoproteins.Metabolic control of Ca2+/calmodulin-dependent protein kinase II (CaMKII)-mediated caspase-2 suppression by the B55β/protein phosphatase 2A (PP2A)The human keratins: biology and pathology.Inhibition of protein phosphatase 2A radiosensitizes pancreatic cancers by modulating CDC25C/CDK1 and homologous recombination repair Placental vasculogenesis is regulated by keratin-mediated hyperoxia in murine decidual tissues S100A8/A9 (calprotectin) negatively regulates G2/M cell cycle progression and growth of squamous cell carcinoma.14-3-3 Binding to ataxin-1(ATXN1) regulates its dephosphorylation at Ser-776 and transport to the nucleus.Phosphatases: the new brakes for cancer development?Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56delta subunit.Identification of testis 14-3-3 binding proteins by tandem affinity purification HEAT repeat 1 motif is required for B56γ-containing protein phosphatase 2A (B56γ-PP2A) holoenzyme assembly and tumor-suppressive function Protein phosphatases and their regulation in the control of mitosis The protein phosphatase 2A inhibitor LB100 sensitizes ovarian carcinoma cells to cisplatin-mediated cytotoxicity Inhibition of protein phosphatase 2A with the small molecule LB100 overcomes cell cycle arrest in osteosarcoma after cisplatin treatment.Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1.

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P2860

Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis.

http://www.wikidata.org/entity/Q41888954

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2006 nî lūn-bûn

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2006年论文

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2006年论文

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name

Role for the PP2A/B56delta pho ...... from Cdc25 to control mitosis.

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type

label

Role for the PP2A/B56delta pho ...... from Cdc25 to control mitosis.

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prefLabel

Role for the PP2A/B56delta pho ...... from Cdc25 to control mitosis.

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Role for the PP2A/B56delta pho ...... from Cdc25 to control mitosis.

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Christopher D Freel

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Craig M Forester

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Jennifer A Perry

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Jung-Hyuck Ahn

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Leta K Nutt

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Melanie J Jardim

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Michael J Thomenius

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Rashid Darbandi

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Sally Kornbluth

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Seth S Margolis

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P2860

The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm

MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation

Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins

Keratin binding to 14-3-3 proteins modulates keratin filaments and hepatocyte mitotic progression

The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon

Cdc55p, the B-type regulatory subunit of protein phosphatase 2A, has multiple functions in mitosis and is required for the kinetochore/spindle checkpoint in Saccharomyces cerevisiae.

Calyculin A-induced vimentin phosphorylation sequesters 14-3-3 and displaces other 14-3-3 partners in vivo

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding

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David M. Virshup

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