A B56gamma mutation in lung cancer disrupts the p53-dependent tumor-suppressor function of protein phosphatase 2A
about
ATM-mediated phosphorylation activates the tumor-suppressive function of B56γ-PP2AThe broken "Off" switch in cancer signaling: PP2A as a regulator of tumorigenesis, drug resistance, and immune surveillancePPP2R5C Couples Hepatic Glucose and Lipid HomeostasisPhosphatase: PP2A structural importance, regulation and its aberrant expression in cancer.Blockade of the BAK hydrophobic groove by inhibitory phosphorylation regulates commitment to apoptosis.Dynamic regulation of extracellular signal-regulated kinase (ERK) by protein phosphatase 2A regulatory subunit B56γ1 in nuclei induces cell migration.Proliferation inhibition and apoptosis induction of imatinib-resistant chronic myeloid leukemia cells via PPP2R5C down-regulation.Functional genetic polymorphisms in PP2A subunit genes confer increased risks of lung cancer in southern and eastern Chinese.Expression and distribution of PPP2R5C gene in leukemia.Regulation of nuclear-cytoplasmic shuttling and function of Family with sequence similarity 13, member A (Fam13a), by B56-containing PP2As and Akt.Human cancer-associated mutations in the Aα subunit of protein phosphatase 2A increase lung cancer incidence in Aα knock-in and knockout mice.Phosphatases: the new brakes for cancer development?Protein Phosphatase 2A Inhibition with LB100 Enhances Radiation-Induced Mitotic Catastrophe and Tumor Growth Delay in Glioblastoma.HEAT repeat 1 motif is required for B56γ-containing protein phosphatase 2A (B56γ-PP2A) holoenzyme assembly and tumor-suppressive functionB'-protein phosphatase 2A is a functional binding partner of delta-retroviral integrase.The B56γ3 regulatory subunit-containing protein phosphatase 2A outcompetes Akt to regulate p27KIP1 subcellular localization by selectively dephosphorylating phospho-Thr157 of p27KIP1.Differential gene expression profiles of PPP2R5C-siRNA-treated malignant T cells.Serine/threonine phosphatases in the DNA damage response and cancer.All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase.B56γ tumor-associated mutations provide new mechanisms for B56γ-PP2A tumor suppressor activityUpregulation of miR-27a contributes to the malignant transformation of human bronchial epithelial cells induced by SV40 small T antigen.α4 is highly expressed in carcinogen-transformed human cells and primary human cancers.(DEAD)-box RNA helicase 3 modulates NF-κB signal pathway by controlling the phosphorylation of PP2A-C subunit.Loss of protein phosphatase 2A regulatory subunit B56δ promotes spontaneous tumorigenesis in vivo.PP2A impaired activity is a common event in acute myeloid leukemia and its activation by forskolin has a potent anti-leukemic effect.
P2860
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P2860
A B56gamma mutation in lung cancer disrupts the p53-dependent tumor-suppressor function of protein phosphatase 2A
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
A B56gamma mutation in lung ca ...... tion of protein phosphatase 2A
@ast
A B56gamma mutation in lung ca ...... tion of protein phosphatase 2A
@en
type
label
A B56gamma mutation in lung ca ...... tion of protein phosphatase 2A
@ast
A B56gamma mutation in lung ca ...... tion of protein phosphatase 2A
@en
prefLabel
A B56gamma mutation in lung ca ...... tion of protein phosphatase 2A
@ast
A B56gamma mutation in lung ca ...... tion of protein phosphatase 2A
@en
P2093
P2860
P356
P1433
P1476
A B56gamma mutation in lung ca ...... tion of protein phosphatase 2A
@en
P2093
P2860
P2888
P304
P356
10.1038/ONC.2010.161
P407
P577
2010-05-17T00:00:00Z
P5875
P6179
1053660053