Myofilament Ca sensitization increases cytosolic Ca binding affinity, alters intracellular Ca homeostasis, and causes pause-dependent Ca-triggered arrhythmia.
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The cardiac muscle duplex as a method to study myocardial heterogeneityResearch priorities in sarcomeric cardiomyopathiesPerturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutationsCardiac inotropy, lusitropy, and Ca2+ handling with major metabolic substrates in rat heartDeregulated Ca2+ cycling underlies the development of arrhythmia and heart disease due to mutant obscurinFRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility.In vitro rescue study of a malignant familial hypertrophic cardiomyopathy phenotype by pseudo-phosphorylation of myosin regulatory light chain.Balanced changes in Ca buffering by SERCA and troponin contribute to Ca handling during β-adrenergic stimulation in cardiac myocytesFamilial hypertrophic cardiomyopathy related cardiac troponin C L29Q mutation alters length-dependent activation and functional effects of phosphomimetic troponin I*Tachycardia-induced silencing of subcellular Ca2+ signaling in atrial myocytes.Comparable calcium handling of human iPSC-derived cardiomyocytes generated by multiple laboratories.In Vivo Analysis of Troponin C Knock-In (A8V) Mice: Evidence that TNNC1 Is a Hypertrophic Cardiomyopathy Susceptibility GeneADP-stimulated contraction: A predictor of thin-filament activation in cardiac disease.Mechanical and energetic properties of papillary muscle from ACTC E99K transgenic mouse models of hypertrophic cardiomyopathy.Myofilament calcium de-sensitization and contractile uncoupling prevent pause-triggered ventricular tachycardia in mouse hearts with chronic myocardial infarctionPharmacological Modulation of Calcium Homeostasis in Familial Dilated Cardiomyopathy: An In Vitro Analysis From an RBM20 Patient-Derived iPSC ModelIonic bases for electrical remodeling of the canine cardiac ventricle.HCM-linked ∆160E cardiac troponin T mutation causes unique progressive structural and molecular ventricular remodeling in transgenic mice.Focal energy deprivation underlies arrhythmia susceptibility in mice with calcium-sensitized myofilaments.Discrete effects of A57G-myosin essential light chain mutation associated with familial hypertrophic cardiomyopathyMuscle dysfunction in hypertrophic cardiomyopathy: what is needed to move to translation?Inherited cardiomyopathies caused by troponin mutations.Alpha-tropomyosin mutations in inherited cardiomyopathies.Genetics of sudden cardiac death caused by ventricular arrhythmias.Cellular and Molecular Aspects of Dyssynchrony and Resynchronization.Early sensitization of myofilaments to Ca2+ prevents genetically linked dilated cardiomyopathy in mice.Proteasome dysfunction in cardiomyopathies.Linking myofilaments to sudden cardiac death: recent advances.Calcium and Excitation-Contraction Coupling in the HeartSystolic [Ca2+ ]i regulates diastolic levels in rat ventricular myocytes.Pathogenesis of Hypertrophic Cardiomyopathy is Mutation Rather Than Disease Specific: A Comparison of the Cardiac Troponin T E163R and R92Q Mouse Models.Life-long tailoring of management for patients with hypertrophic cardiomyopathy : Awareness and decision-making in changing scenarios.Synergistic role of ADP and Ca(2+) in diastolic myocardial stiffness.Familial hypertrophic cardiomyopathy: is the Frank-Starling law kaput?Clinical outcomes associated with sarcomere mutations in hypertrophic cardiomyopathy: a meta-analysis on 7675 individuals.Myofilament Calcium-Buffering Dependent Action Potential Triangulation in Human-Induced Pluripotent Stem Cell Model of Hypertrophic Cardiomyopathy.Hypertrophic cardiomyopathy-linked mutation in troponin T causes myofibrillar disarray and pro-arrhythmic action potential changes in human iPSC cardiomyocytes.Remodeling of repolarization and arrhythmia susceptibility in a myosin-binding protein C knockout mouse model.The structural basis of alpha-tropomyosin linked (Asp230Asn) familial dilated cardiomyopathy.Sexual dimorphic response to exercise in hypertrophic cardiomyopathy-associated MYBPC3-targeted knock-in mice.
P2860
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P2860
Myofilament Ca sensitization increases cytosolic Ca binding affinity, alters intracellular Ca homeostasis, and causes pause-dependent Ca-triggered arrhythmia.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Myofilament Ca sensitization i ...... ndent Ca-triggered arrhythmia.
@en
type
label
Myofilament Ca sensitization i ...... ndent Ca-triggered arrhythmia.
@en
prefLabel
Myofilament Ca sensitization i ...... ndent Ca-triggered arrhythmia.
@en
P2093
P2860
P1433
P1476
Myofilament Ca sensitization i ...... endent Ca-triggered arrhythmia
@en
P2093
Dmytro Kryshtal
Franz J Baudenbacher
Hyun Seok Hwang
Oleksiy Gryshchenko
Raghav Venkataraman
Sabine Huke
Tilmann Schober
P2860
P304
P356
10.1161/CIRCRESAHA.112.270041
P577
2012-05-29T00:00:00Z