The occurrence of aging-dependent reticulon 3 immunoreactive dystrophic neurites decreases cognitive function.
about
Widespread distribution of reticulon-3 in various neurodegenerative diseasesRTN/Nogo in forming Alzheimer's neuritic plaques.Impact of RTN3 deficiency on expression of BACE1 and amyloid deposition.A knockin mouse model of spinocerebellar ataxia type 3 exhibits prominent aggregate pathology and aberrant splicing of the disease gene transcript.Increased expression of reticulon 3 in neurons leads to reduced axonal transport of β site amyloid precursor protein-cleaving enzyme 1.Reduced amyloid deposition in mice overexpressing RTN3 is adversely affected by preformed dystrophic neurites.The role of Nogo-A in axonal plasticity, regrowth and repair.Inhibition of glial hemichannels by boldine treatment reduces neuronal suffering in a murine model of Alzheimer's disease.Astroglial connexin43 contributes to neuronal suffering in a mouse model of Alzheimer's diseaseThe Alzheimer's β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques.Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer's disease.Preventing formation of reticulon 3 immunoreactive dystrophic neurites improves cognitive function in mice.α-secretase cleaved amyloid precursor protein (APP) accumulates in cholinergic dystrophic neurites in normal, aged hippocampus.
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P2860
The occurrence of aging-dependent reticulon 3 immunoreactive dystrophic neurites decreases cognitive function.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
The occurrence of aging-depend ...... decreases cognitive function.
@en
type
label
The occurrence of aging-depend ...... decreases cognitive function.
@en
prefLabel
The occurrence of aging-depend ...... decreases cognitive function.
@en
P2093
P2860
P1476
The occurrence of aging-depend ...... decreases cognitive function.
@en
P2093
Marguerite Prior
Riqiang Yan
Xiangyou Hu
P2860
P304
P356
10.1523/JNEUROSCI.5887-08.2009
P407
P577
2009-04-01T00:00:00Z