Efficient TGFβ-induced epithelial-mesenchymal transition depends on hyaluronan synthase HAS2. - Wikidata - awgldk - TriplyDB

Efficient TGFβ-induced epithelial-mesenchymal transition depends on hyaluronan synthase HAS2.

Efficient TGFβ-induced epithelial-mesenchymal transition depends on hyaluronan synthase HAS2.

http://www.wikidata.org/entity/Q41898534

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Mechanisms of TGFβ-Induced Epithelial-Mesenchymal Transition Key Roles of Hyaluronan and Its CD44 Receptor in the Stemness and Survival of Cancer Stem Cells Collagen VI and hyaluronan: the common role in breast cancer Targeting TGF-β signaling in cancer The wound healing, chronic fibrosis, and cancer progression triad HYAL-2-WWOX-SMAD4 Signaling in Cell Death and Anticancer Response RNA-Seq and CyTOF immuno-profiling of regenerating lacrimal glands identifies a novel subset of cells expressing muscle-related proteins The motile breast cancer phenotype roles of proteoglycans/glycosaminoglycans.Excessive hyaluronan production promotes acquisition of cancer stem cell signatures through the coordinated regulation of Twist and the transforming growth factor β (TGF-β)-Snail signaling axis.Hyaluronan synthase 2 protects skin fibroblasts against apoptosis induced by environmental stress.Fluorescence resonance energy transfer (FRET) and proximity ligation assays reveal functionally relevant homo- and heteromeric complexes among hyaluronan synthases HAS1, HAS2, and HAS3 Transforming growth factor-β1 induces EMT by the transactivation of epidermal growth factor signaling through HA/CD44 in lung and breast cancer cells The deubiquitinating enzymes USP4 and USP17 target hyaluronan synthase 2 and differentially affect its function.Proteoglycans and their roles in brain cancer.Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-β1 A new perspective of vasculogenic mimicry: EMT and cancer stem cells (Review).A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancer Protein conformation as a regulator of cell-matrix adhesion.Targeting hyaluronic acid family for cancer chemoprevention and therapy.Biomechanics of TGFβ-induced epithelial-mesenchymal transition: implications for fibrosis and cancer Sugars in the microenvironment: the sticky problem of HA turnover in tumors.Epithelial-mesenchymal transition in liver fibrosis Role of Pericellular Matrix in the Regulation of Cancer Stemness.Long noncoding RNA HAS2-AS1 mediates hypoxia-induced invasiveness of oral squamous cell carcinoma.CD44S-hyaluronan interactions protect cells resulting from EMT against anoikis.TWEAK enhances TGF-β-induced epithelial-mesenchymal transition in human bronchial epithelial cells.Hyaluronic acid in digestive cancers.Crk-like adapter protein is required for TGF-β-induced AKT and ERK-signaling pathway in epithelial ovarian carcinomas.Differential expression of hyaluronan synthase 2 in breast carcinoma and its biological significance.Tissue mechanics regulate brain development, homeostasis and disease.Accumulation of extracellular hyaluronan by hyaluronan synthase 3 promotes tumor growth and modulates the pancreatic cancer microenvironment.Hyaluronan synthase 2 is an adverse prognostic marker in androgen receptor-negative breast cancer.Hyaluronan synthases (HAS1-3) in stromal and malignant cells correlate with breast cancer grade and predict patient survival.Human hyaluronic acid synthase-1 promotes malignant transformation via epithelial-to-mesenchymal transition, micronucleation and centrosome abnormalities.Role of the extracellular matrix in cancer-associated epithelial to mesenchymal transition phenomenon.Multi-functional, multicompartmental hyaluronan-binding protein 1 (HABP1/p32/gC1qR): implication in cancer progression and metastasis.Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas.

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Efficient TGFβ-induced epithelial-mesenchymal transition depends on hyaluronan synthase HAS2.

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Efficient TGFβ-induced epithel ...... s on hyaluronan synthase HAS2.

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A D Theocharis

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B Bernert

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C-H Heldin

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A novel unstable duplication upstream of HAS2 predisposes to a breed-defining skin phenotype and a periodic fever syndrome in Chinese Shar-Pei dogs

Hyaluronan synthase 2 (HAS2) promotes breast cancer cell invasion by suppression of tissue metalloproteinase inhibitor 1 (TIMP-1)

Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB

The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase

Functional cloning of the cDNA for a human hyaluronan synthase

Expression of human hyaluronan synthases in response to external stimuli

Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism

Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme

Fibronectin expression modulates mammary epithelial cell proliferation during acinar differentiation

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