Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity.
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Genetic insights into the mechanisms of Fgf signalingGrb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancerCompetition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion.Pathogenic Cysteine Removal Mutations in FGFR Extracellular Domains Stabilize Receptor Dimers and Perturb the TM Dimer Structure.The Fibroblast Growth Factor signaling pathwayInhibition of SHP2 in basal-like and triple-negative breast cells induces basal-to-luminal transition, hormone dependency, and sensitivity to anti-hormone treatment.A novel dual kinase function of the RET proto-oncogene negatively regulates activating transcription factor 4-mediated apoptosis.T cell activation is reduced by the catalytically inactive form of protein tyrosine phosphatase SHP-2Grb2 monomer-dimer equilibrium determines normal versus oncogenic function.Functions of Shp2 in cancer.Developmental transcriptome analysis and identification of genes involved in formation of intestinal air-breathing function of Dojo loach, Misgurnus anguillicaudatusRasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth.Next generation sequencing reveals regulation of distinct Aedes microRNAs during chikungunya virus development.Grb2 promotes integrin-induced focal adhesion kinase (FAK) autophosphorylation and directs the phosphorylation of protein tyrosine phosphatase α by the Src-FAK kinase complex.Mechanism of FGF receptor dimerization and activation.A small peptide promotes EphA2 kinase-dependent signaling by stabilizing EphA2 dimers.SHP2 Regulates the Osteogenic Fate of Growth Plate Hypertrophic ChondrocytesFeedback regulation of RTK signaling in development.
P2860
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P2860
Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Grb2 controls phosphorylation ...... and Shp2 phosphatase activity.
@en
Grb2 controls phosphorylation ...... and Shp2 phosphatase activity.
@en-gb
type
label
Grb2 controls phosphorylation ...... and Shp2 phosphatase activity.
@en
Grb2 controls phosphorylation ...... and Shp2 phosphatase activity.
@en-gb
prefLabel
Grb2 controls phosphorylation ...... and Shp2 phosphatase activity.
@en
Grb2 controls phosphorylation ...... and Shp2 phosphatase activity.
@en-gb
P2093
P2860
P356
P1476
Grb2 controls phosphorylation ...... and Shp2 phosphatase activity.
@en
P2093
Chi-Chuan Lin
Fernando A Melo
James A Levitt
Kin M Suen
Zamal Ahmed
P2860
P304
P356
10.1083/JCB.201204106
P407
P577
2013-02-01T00:00:00Z