Stabilized cyclopropane analogs of the splicing inhibitor FD-895
about
Modulating splicing with small molecular inhibitors of the spliceosomeSpliceostatin hemiketal biosynthesis in Burkholderia spp. is catalyzed by an iron/α-ketoglutarate-dependent dioxygenase.Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B.Twelve-membered macrolactones: privileged scaffolds for the development of new therapeutics.Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stagesCoherence between cellular responses and in vitro splicing inhibition for the anti-tumor drug pladienolide B and its analogs.Design and synthesis of analogues of natural products.Pre-mRNA splicing-modulatory pharmacophores: the total synthesis of herboxidiene, a pladienolide-herboxidiene hybrid analog and related derivatives.Discoveries, target identifications, and biological applications of natural products that inhibit splicing factor 3B subunit 1.Splicing factor gene mutations in hematologic malignancies.A Challenging Pie to Splice: Drugging the Spliceosome.
P2860
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P2860
Stabilized cyclopropane analogs of the splicing inhibitor FD-895
description
2013 nî lūn-bûn
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
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2013年论文
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name
Stabilized cyclopropane analogs of the splicing inhibitor FD-895
@en
type
label
Stabilized cyclopropane analogs of the splicing inhibitor FD-895
@en
prefLabel
Stabilized cyclopropane analogs of the splicing inhibitor FD-895
@en
P2093
P2860
P356
P1476
Stabilized cyclopropane analogs of the splicing inhibitor FD-895
@en
P2093
Deepak Kumar
James J La Clair
Januario E Castro
Michael D Burkart
Reymundo Villa
Thomas J Kipps
P2860
P304
P356
10.1021/JM400861T
P407
P577
2013-08-21T00:00:00Z