Design, synthesis and initial biological evaluation of a novel pladienolide analog scaffold.
about
Modulating splicing with small molecular inhibitors of the spliceosomeTwelve-membered macrolactones: privileged scaffolds for the development of new therapeutics.Enantioselective total synthesis of pladienolide B: a potent spliceosome inhibitorInterchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stagesCoherence between cellular responses and in vitro splicing inhibition for the anti-tumor drug pladienolide B and its analogs.The development and application of small molecule modulators of SF3b as therapeutic agents for cancer.Design and synthesis of analogues of natural products.Pre-mRNA splicing-modulatory pharmacophores: the total synthesis of herboxidiene, a pladienolide-herboxidiene hybrid analog and related derivatives.Discoveries, target identifications, and biological applications of natural products that inhibit splicing factor 3B subunit 1.Stabilized cyclopropane analogs of the splicing inhibitor FD-895Optimization of antitumor modulators of pre-mRNA splicing.A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore.
P2860
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P2860
Design, synthesis and initial biological evaluation of a novel pladienolide analog scaffold.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Design, synthesis and initial ...... pladienolide analog scaffold.
@ast
Design, synthesis and initial ...... pladienolide analog scaffold.
@en
type
label
Design, synthesis and initial ...... pladienolide analog scaffold.
@ast
Design, synthesis and initial ...... pladienolide analog scaffold.
@en
prefLabel
Design, synthesis and initial ...... pladienolide analog scaffold.
@ast
Design, synthesis and initial ...... pladienolide analog scaffold.
@en
P2093
P2860
P356
P1433
P1476
Design, synthesis and initial ...... pladienolide analog scaffold.
@en
P2093
Alan Pourpak
Mahesh Kumar Gundluru
Stephan W Morris
Thomas R Webb
Xiaoli Cui
P2860
P304
P356
10.1039/C1MD00040C
P577
2011-01-01T00:00:00Z