Distinct tau prion strains propagate in cells and mice and define different tauopathies. - Wikidata - awgldk - TriplyDB

Distinct tau prion strains propagate in cells and mice and define different tauopathies.

Distinct tau prion strains propagate in cells and mice and define different tauopathies.

http://www.wikidata.org/entity/Q41904960

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Propagation of prions causing synucleinopathies in cultured cells Unified theory of Alzheimer's disease (UTAD): implications for prevention and curative therapy Molecular Mechanisms in the Pathogenesis of Alzheimer's disease and Tauopathies-Prion-Like Seeded Aggregation and Phosphorylation Insights into Mechanisms of Chronic Neurodegeneration Neurodegenerative diseases: expanding the prion concept Prion-like properties of Tau protein: the importance of extracellular Tau as a therapeutic target Depletion of microglia and inhibition of exosome synthesis halt tau propagation.Tau physiology and pathomechanisms in frontotemporal lobar degeneration Tau Structures Spreading of pathology in neurodegenerative diseases: a focus on human studies Role of Different Alpha-Synuclein Strains in Synucleinopathies, Similarities with other Neurodegenerative Diseases Three dimensions of the amyloid hypothesis: time, space and 'wingmen'The preclinical phase of the pathological process underlying sporadic Alzheimer's disease Legal but lethal: functional protein aggregation at the verge of toxicity The emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease Analyzing dendritic spine pathology in Alzheimer's disease: problems and opportunities Post-translational modifications in PrP expand the conformational diversity of prions in vivo Different pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer's disease and frontotemporal lobar degeneration Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies Propagation of tau pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies.Glial contributions to neurodegeneration in tauopathies.Roles of tau protein in health and disease.Cytoplasmic poly-GA aggregates impair nuclear import of TDP-43 in C9orf72 ALS/FTLD.Characterization of tau prion seeding activity and strains from formaldehyde-fixed tissue.Types and Strains: Their Essential Role in Understanding Protein Aggregation in Neurodegenerative Diseases.RNA stores tau reversibly in complex coacervates Is there a risk of prion-like disease transmission by Alzheimer- or Parkinson-associated protein particles?Proteopathic tau seeding predicts tauopathy in vivo.Models of β-amyloid induced Tau-pathology: the long and "folded" road to understand the mechanism.Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer's disease or corticobasal degeneration brains Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer's disease Amyloid polymorphism: structural basis and neurobiological relevance.Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice.Mechanism of scrapie prion precipitation with phosphotungstate anions.Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation.Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity.Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake.Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains.Host Determinants of Prion Strain Diversity Independent of Prion Protein Genotype.Amino Acid Proximities in Two Sup35 Prion Strains Revealed by Chemical Cross-linking.

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P2860

Distinct tau prion strains propagate in cells and mice and define different tauopathies.

http://www.wikidata.org/entity/Q41904960

description

2014 nî lūn-bûn

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2014年の論文

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2014年論文

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2014年论文

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2014年论文

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2014年论文

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name

Distinct tau prion strains propagate in cells and mice and define different tauopathies.

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type

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Distinct tau prion strains propagate in cells and mice and define different tauopathies.

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Distinct tau prion strains propagate in cells and mice and define different tauopathies.

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J.NEURON.2014.04.047

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Distinct tau prion strains propagate in cells and mice and define different tauopathies.

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Aimin Li

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Alex C Foley

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Apurwa M Sharma

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Hilda Mirbaha

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Timothy M Miller

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P2860

Darwinian evolution of prions in cell culture

Paired helical filaments from Alzheimer disease brain induce intracellular accumulation of Tau protein in aggresomes

Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

Transmission and spreading of tauopathy in transgenic mouse brain

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates

Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

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