SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver. - Wikidata - awgldk - TriplyDB

SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver.

SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver.

http://www.wikidata.org/entity/Q41908225

about

YAP and TAZ: a nexus for Hippo signaling and beyond Role of the protein tyrosine phosphatase Shp2 in homeostasis of the intestinal epithelium Genomic profiling reveals mutational landscape in parathyroid carcinomas Architecture of the RNA polymerase II-Paf1C-TFIIS transcription elongation complex.The in vitro and vivo effects of nuclear and cytosolic parafibromin expression on the aggressive phenotypes of colorectal cancer cells: a search of potential gene therapy target.Characterization of a new CDC73 missense mutation that impairs Parafibromin expression and nucleolar localization.SHP2E76K mutant promotes lung tumorigenesis in transgenic mice Critical role of SHP2 (PTPN11) signaling in germinal center-derived lymphoma.CTR9, a component of PAF complex, controls elongation block at the c-Fos locus via signal-dependent regulation of chromatin-bound NELF dissociation.Potentiation of Helicobacter pylori CagA protein virulence through homodimerization Contributions of Rad9 to tumorigenesis.A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice.The many roles of the conserved eukaryotic Paf1 complex in regulating transcription, histone modifications, and disease states.Menin mediates epigenetic regulation via histone H3 lysine 9 methylation.New and Unexpected Biological Functions for the Src-Homology 2 Domain-Containing Phosphatase SHP-2 in the Gastrointestinal Tract.PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways.Diagnosis and management of parathyroid cancer.Role of protein tyrosine phosphatases in the modulation of insulin signaling and their implication in the pathogenesis of obesity-linked insulin resistance.Shp2 promotes liver cancer stem cell expansion by augmenting β-catenin signaling and predicts chemotherapeutic response of patients.RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II.Ctr9, a Key Component of the Paf1 Complex, Affects Proliferation and Terminal Differentiation in the Developing Drosophila Nervous System.Action and function of Wnt/β-catenin signaling in the progression from chronic hepatitis C to hepatocellular carcinoma.Structure and function of Helicobacter pylori CagA, the first-identified bacterial protein involved in human cancer.Expression of parafibromin in major renal cell tumors.Tyrosyl phosphorylation toggles a Runx1 switch.Nuclear Shp2 directs normal embryo implantation via facilitating the ERα tyrosine phosphorylation by the Src kinase.Crystal structure of the N-terminal domain of human CDC73 and its implications for the hyperparathyroidism-jaw tumor (HPT-JT) syndrome.The roles of parafibromin expression in ovarian epithelial carcinomas: a marker for differentiation and prognosis and a target for gene therapy.The clinicopathological and prognostic significances of CDC73 expression in cancers: a bioinformatics analysis.Paf1 and Ctr9, core components of the PAF1 complex, maintain low levels of telomeric repeat containing RNA.Emerging Insights into the Roles of the Paf1 Complex in Gene Regulation.PAF1 complex component Leo1 helps recruit Drosophila Myc to promoters.Beta-catenin recruits CDC73 and LEO1 Large-scale analysis of lysine SUMOylation by SUMO remnant immunoaffinity profiling.Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition.Co-occurrence of hypertrophic cardiomyopathy and myeloproliferative disorder in a neonate with Noonan syndrome carrying Thr73Ile mutation in PTPN11.PAF1 complex interactions with SETDB1 mediate promoter H3K9 methylation and transcriptional repression of Hoxa9 and Meis1 in acute myeloid leukemia.

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P2860

SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver.

http://www.wikidata.org/entity/Q41908225

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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2011年论文

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2011年论文

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name

SHP2 tyrosine phosphatase conv ...... ressor to an oncogenic driver.

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type

label

SHP2 tyrosine phosphatase conv ...... ressor to an oncogenic driver.

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prefLabel

SHP2 tyrosine phosphatase conv ...... ressor to an oncogenic driver.

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P356

J.MOLCEL.2011.05.014

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P1476

SHP2 tyrosine phosphatase conv ...... ressor to an oncogenic driver.

@en

P2093

Atsushi Takahashi

http://www.w3.org/2001/XMLSchema#string

Azadeh Seidi

http://www.w3.org/2001/XMLSchema#string

Benjamin G Neel

http://www.w3.org/2001/XMLSchema#string

Chikashi Obuse

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Ippei Kikuchi

http://www.w3.org/2001/XMLSchema#string

Masanori Hatakeyama

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Minerva Fernandez

http://www.w3.org/2001/XMLSchema#string

Naomi Ohnishi

http://www.w3.org/2001/XMLSchema#string

Robert Karisch

http://www.w3.org/2001/XMLSchema#string

Ryouhei Tsutsumi

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P2860

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS

Parafibromin inhibits cancer cell growth and causes G1 phase arrest

The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene

Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo

Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair

The parafibromin tumor suppressor protein is part of a human Paf1 complex

Wnt/beta-catenin signaling: components, mechanisms, and diseases

Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia

The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation

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45-56

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scholarly article

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10.1016/J.MOLCEL.2011.05.014

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1

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43

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Matthew Meyerson

Orit Rozenblatt-Rosen

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2011-07-01T00:00:00Z

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51465006

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21726809

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5101830

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