about
Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus.RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediateA mammalian microRNA expression atlas based on small RNA library sequencingStructural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-ICyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP SynthaseStructure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA5'-Triphosphate RNA is the ligand for RIG-IWhere Failure Is Not an Option -Personalized Medicine in AstronautsShock waves: a novel method for cytoplasmic delivery of antisense oligonucleotides.Antisense therapy in oncology: new hope for an old idea?Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphatesRIG-I detects triphosphorylated RNA of Listeria monocytogenes during infection in non-immune cellsA human in vitro whole blood assay to predict the systemic cytokine response to therapeutic oligonucleotides including siRNAEfficient solid-phase synthesis of pppRNA by using product-specific labeling.Binding-pocket and lid-region substitutions render human STING sensitive to the species-specific drug DMXAA.Therapeutic tissue regeneration by a macrophage colony-stimulating factor Fc conjugate.Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNAATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA.siRNA and isRNA: two edges of one sword.VKORC1-dependent pharmacokinetics of intravenous and oral phylloquinone (vitamin K1) mixed micelles formulation.RNA recognition via TLR7 and TLR8.Accessing the therapeutic potential of immunostimulatory nucleic acids.Approaching the RNA ligand for RIG-I?The chase for the RIG-I ligand--recent advances.Dendritic cell vaccination in human melanoma: relationships between clinical effects and vaccine parameters.Nucleic acid adjuvants: toward an educated vaccine.Exosomes as nucleic acid nanocarriers.Turning tumors into vaccines: co-opting the innate immune system.Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides.IL-12p70-dependent Th1 induction by human B cells requires combined activation with CD40 ligand and CpG DNA.Structural studies of oligonucleotides containing G-quadruplex motifs using AFM.Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-alpha induction in plasmacytoid dendritic cells.Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells.[Basic principles, planning and implementation of non-commercial clinical trials].Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression.Discriminating self from non-self in nucleic acid sensing.Yeast virus-derived stimulator of the innate immune system augments the efficacy of virus vector-based immunotherapy.Clinical Performance of CEA, CA19-9, CA15-3, CA125 and AFP in Gastrointestinal Cancer Using LOCI™-based Assays.G-rich DNA-induced stress response blocks type-I-IFN but not CXCL10 secretion in monocytes.
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description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Gunther Hartmann
@ast
Gunther Hartmann
@en
Gunther Hartmann
@es
Gunther Hartmann
@sl
type
label
Gunther Hartmann
@ast
Gunther Hartmann
@en
Gunther Hartmann
@es
Gunther Hartmann
@sl
prefLabel
Gunther Hartmann
@ast
Gunther Hartmann
@en
Gunther Hartmann
@es
Gunther Hartmann
@sl
P108
P1053
P-7492-2017
P106
P21
P31
P3829
P496
0000-0003-1021-2018