Fluorescence microscopic demonstration of cathepsin K activity as the major lysosomal cysteine proteinase in osteoclasts.
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Proteolytic excision of a repressive loop domain in tartrate-resistant acid phosphatase by cathepsin K in osteoclastsPolarization and secretion of cathepsin K precede tartrate-resistant acid phosphatase secretion to the ruffled border area during the activation of matrix-resorbing clastsAcid attack and cathepsin K in bone resorption around total hip replacement prosthesis.Inhibition of cathepsin activity in a cell-based assay by a light-activated ruthenium compound.Thyroid functions of mouse cathepsins B, K, and L.Osteoclasts from patients with autosomal dominant osteopetrosis type I caused by a T253I mutation in low-density lipoprotein receptor-related protein 5 are normal in vitro, but have decreased resorption capacity in vivoImpaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient miceEffect of Three Statins on Glucose Uptake of Cardiomyocytes and its MechanismCCL3 and MMP-9 are induced by TL1A during death receptor 3 (TNFRSF25)-dependent osteoclast function and systemic bone loss.Rab27A regulates transport of cell surface receptors modulating multinucleation and lysosome-related organelles in osteoclasts.The dental resin monomers HEMA and TEGDMA have inhibitory effects on osteoclast differentiation with low cytotoxicity.Dual Effects of Liquiritigenin on the Proliferation of Bone Cells: Promotion of Osteoblast Differentiation and Inhibition of Osteoclast Differentiation.Punicalagin attenuates osteoclast differentiation by impairing NFATc1 expression and blocking Akt- and JNK-dependent pathways.Porcine enamel matrix derivative enhances trabecular bone regeneration during wound healing of injured rat femur.Inhibitory effects of tert-butylhydroquinone on osteoclast differentiation via up-regulation of heme oxygenase-1 and down-regulation of HMGB1 release and NFATc1 expression.Effects of brefeldin-A: potent inhibitor of intracellular protein transport on ultrastructure and resorptive function of cultured osteoclasts.Disruption of the Man-6-P targeting pathway in mice impairs osteoclast secretory lysosome biogenesis.Quantification of the expression levels of lysosomal cysteine proteinases in purified human osteoclastic cells by competitive RT-PCR.Female estrogen receptor beta-/- mice are partially protected against age-related trabecular bone loss.Immunolocalization of vacuolar-type H+-ATPase, cathepsin K, matrix metalloproteinase-9, and receptor activator of NFkappaB ligand in odontoclasts during physiological root resorption of human deciduous teeth.Reciprocal effects of Interferon-γ and IL-4 on differentiation to osteoclast-like cells by RANKL or LPS.Recruitment of osteoclasts in the mandible of osteopetrotic (op/op) mice.Effects of enamel matrix derivative to titanium implantation in rat femurs.Role of NOD1 polymorphism in susceptibility and clinical progression of rheumatoid arthritis.Cathepsin K modulates invasion, migration and adhesion of oral squamous cell carcinomas in vitro.Upregulation of miR-146a increases cisplatin sensitivity of the non-small cell lung cancer A549 cell line by targeting JNK-2.A Matrine Derivative M54 Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss by Targeting Ribosomal Protein S5.Suppression of RANKL-dependent heme oxygenase-1 is required for high mobility group box 1 release and osteoclastogenesis.Cobalt protoporphyrin represses osteoclastogenesis through blocking multiple signaling pathways.Castalagin Exerts Inhibitory Effects on Osteoclastogenesis Through Blocking a Broad Range of Signaling Pathways with Low Cytotoxicity.Genetic backgrounds and redox conditions influence morphological characteristics and cell differentiation of osteoclasts in mice.Determination of bone markers in pycnodysostosis: effects of cathepsin K deficiency on bone matrix degradation.Effects of antisense mediated inhibition of cathepsin K on human osteoclasts obtained from peripheral blood
P2860
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P2860
Fluorescence microscopic demonstration of cathepsin K activity as the major lysosomal cysteine proteinase in osteoclasts.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Fluorescence microscopic demon ...... ine proteinase in osteoclasts.
@en
type
label
Fluorescence microscopic demon ...... ine proteinase in osteoclasts.
@en
prefLabel
Fluorescence microscopic demon ...... ine proteinase in osteoclasts.
@en
P2093
P1476
Fluorescence microscopic demon ...... eine proteinase in osteoclasts
@en
P2093
P304
P356
10.1093/OXFORDJOURNALS.JBCHEM.A022001
P577
1998-04-01T00:00:00Z