M184I/V substitutions and E138K/M184I/V double substitutions in HIV reverse transcriptase do not significantly affect the antiviral activity of EFdA.

about

M184I/V substitutions and E138K/M184I/V double substitutions in HIV reverse transcriptase do not significantly affect the antiviral activity of EFdA.

Item

http://www.wikidata.org/entity/Q41927879

description

2017 nî lūn-bûn

@nan

2017年の論文

@ja

2017年論文

@yue

2017年論文

@zh-hant

2017年論文

@zh-hk

2017年論文

@zh-mo

2017年論文

@zh-tw

2017年论文

@wuu

2017年论文

@zh

2017年论文

@zh-cn

name

M184I/V substitutions and E138 ...... he antiviral activity of EFdA.

@en

type

Item

label

M184I/V substitutions and E138 ...... he antiviral activity of EFdA.

@en

prefLabel

M184I/V substitutions and E138 ...... he antiviral activity of EFdA.

@en

P1476

M184I/V substitutions and E138 ...... he antiviral activity of EFdA.

@en

P2093

Bluma G Brenner

http://www.w3.org/2001/XMLSchema#string

Hongtao Xu

http://www.w3.org/2001/XMLSchema#string

Mark A Wainberg

http://www.w3.org/2001/XMLSchema#string

Maureen Oliveira

http://www.w3.org/2001/XMLSchema#string

Ruxandra-Ilinca Ibanescu

http://www.w3.org/2001/XMLSchema#string

Thibault Mesplède

http://www.w3.org/2001/XMLSchema#string

P2860

Efficient Inhibition of HIV Replication in the Gastrointestinal and Female Reproductive Tracts of Humanized BLT Mice by EFdA

Oral administration of the nucleoside EFdA (4'-ethynyl-2-fluoro-2'-deoxyadenosine) provides rapid suppression of HIV viremia in humanized mice and favorable pharmacokinetic properties in mice and the rhesus macaque

Characterization of the E138K resistance mutation in HIV-1 reverse transcriptase conferring susceptibility to etravirine in B and non-B HIV-1 subtypes.

2'-deoxy-4'-C-ethynyl-2-halo-adenosines active against drug-resistant human immunodeficiency virus type 1 variants.

Compensation by the E138K mutation in HIV-1 reverse transcriptase for deficits in viral replication capacity and enzyme processivity associated with the M184I/V mutations.

Interaction of reverse transcriptase (RT) mutations conferring resistance to lamivudine and etravirine: effects on fitness and RT activity of human immunodeficiency virus type 1.

Activity against human immunodeficiency virus type 1, intracellular metabolism, and effects on human DNA polymerases of 4'-ethynyl-2-fluoro-2'-deoxyadenosine.

Response of simian immunodeficiency virus to the novel nucleoside reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine in vitro and in vivo.

Molecular mechanism of antagonism between the Y181C and E138K mutations in HIV-1 reverse transcriptase

Structural basis of HIV inhibition by translocation-defective RT inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA)

P31

scholarly article

P356

10.1093/JAC/DKX280

http://www.w3.org/2001/XMLSchema#string

P407

English

P577

2017-08-22T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

28961903

http://www.w3.org/2001/XMLSchema#string

P932

5890679

http://www.w3.org/2001/XMLSchema#string