Molecular mechanism of antagonism between the Y181C and E138K mutations in HIV-1 reverse transcriptase
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Current perspectives on HIV-1 antiretroviral drug resistanceExposure to MIV-150 from a high-dose intravaginal ring results in limited emergence of drug resistance mutations in SHIV-RT infected rhesus macaquesImpact of Y181C and/or H221Y mutation patterns of HIV-1 reverse transcriptase on phenotypic resistance to available non-nucleoside and nucleoside inhibitors in China.Effects of the W153L substitution in HIV reverse transcriptase on viral replication and drug resistance to multiple categories of reverse transcriptase inhibitors.Drug susceptibility to etravirine and darunavir among Human Immunodeficiency Virus Type 1-derived pseudoviruses in treatment-experienced patients with HIV/AIDS in South Korea.Effect of mutations at position E138 in HIV-1 reverse transcriptase and their interactions with the M184I mutation on defining patterns of resistance to nonnucleoside reverse transcriptase inhibitors rilpivirine and etravirine.HIV-1 capsid uncoating initiates after the first strand transfer of reverse transcription.Role of the K101E substitution in HIV-1 reverse transcriptase in resistance to rilpivirine and other nonnucleoside reverse transcriptase inhibitorsThe connection domain mutation N348I in HIV-1 reverse transcriptase enhances resistance to etravirine and rilpivirine but restricts the emergence of the E138K resistance mutation by diminishing viral replication capacity.Design, synthesis, and biological evaluation of novel trifluoromethyl indoles as potent HIV-1 NNRTIs with an improved drug resistance profile.M184I/V substitutions and E138K/M184I/V double substitutions in HIV reverse transcriptase do not significantly affect the antiviral activity of EFdA.
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P2860
Molecular mechanism of antagonism between the Y181C and E138K mutations in HIV-1 reverse transcriptase
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2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
@zh-my
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2012年學術文章
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name
Molecular mechanism of antagon ...... in HIV-1 reverse transcriptase
@ast
Molecular mechanism of antagon ...... in HIV-1 reverse transcriptase
@en
type
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Molecular mechanism of antagon ...... in HIV-1 reverse transcriptase
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Molecular mechanism of antagon ...... in HIV-1 reverse transcriptase
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Molecular mechanism of antagon ...... in HIV-1 reverse transcriptase
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Molecular mechanism of antagon ...... in HIV-1 reverse transcriptase
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P2093
P2860
P356
P1433
P1476
Molecular mechanism of antagon ...... in HIV-1 reverse transcriptase
@en
P2093
Eugene L Asahchop
Hong-Tao Xu
Mark A Wainberg
Matthew McCallum
Maureen Oliveira
Peter K Quashie
Yingshan Han
Yudong Quan
P2860
P304
12983-12990
P356
10.1128/JVI.02005-12
P407
P577
2012-09-19T00:00:00Z