Cardiomyopathy mutations reveal variable region of myosin converter as major element of cross-bridge compliance.
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Poorly understood aspects of striated muscle contractionUnderstanding cardiomyopathy phenotypes based on the functional impact of mutations in the myosin motorTargets for therapy in sarcomeric cardiomyopathiesVisualizing key hinges and a potential major source of compliance in the lever arm of myosinProcessive Steps in the Reverse Direction Require Uncoupling of the Lead Head Lever Arm of Myosin VIMyofibrillar myopathy caused by a mutation in the motor domain of mouse MyHC IIbMultidimensional structure-function relationships in human β-cardiac myosin from population-scale genetic variation.Mechanical analysis of Drosophila indirect flight and jump musclesBiophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy.Myosin individualized: single nucleotide polymorphisms in energy transduction.Axial and radial forces of cross-bridges depend on lattice spacing.β-Myosin heavy chain variant Val606Met causes very mild hypertrophic cardiomyopathy in mice, but exacerbates HCM phenotypes in mice carrying other HCM mutationsIs the cross-bridge stiffness proportional to tension during muscle fiber activation?The influence of myosin converter and relay domains on cross-bridge kinetics of Drosophila indirect flight muscle.Modulating Beta-Cardiac Myosin Function at the Molecular and Tissue Levels.Disrupting the myosin converter-relay interface impairs Drosophila indirect flight muscle performanceUnequal allelic expression of wild-type and mutated β-myosin in familial hypertrophic cardiomyopathy.Structural and functional aspects of the myosin essential light chain in cardiac muscle contraction.Alternative relay and converter domains tune native muscle myosin isoform function in Drosophila.Mechanics of myosin function in white muscle fibres of the dogfish, Scyliorhinus canicula.An embryonic myosin converter domain influences Drosophila indirect flight muscle stretch activation, power generation and flight.Muscle dysfunction in hypertrophic cardiomyopathy: what is needed to move to translation?The fraction of strongly bound cross-bridges is increased in mice that carry the myopathy-linked myosin heavy chain mutation MYH4L342Q.Elevated rates of force development and MgATP binding in F764L and S532P myosin mutations causing dilated cardiomyopathy.Familial hypertrophic cardiomyopathy: functional variance among individual cardiomyocytes as a trigger of FHC-phenotype development.A cross-bridge cycle with two tension-generating steps simulates skeletal muscle mechanicsTwo strikes and you're out: gene-gene mutation interactions in HCM.Force-generating capacity of human myosin isoforms extracted from single muscle fibre segments.Inherent force-dependent properties of β-cardiac myosin contribute to the force-velocity relationship of cardiac muscle.The contribution of mutations in MYH7 to the onset of cardiomyopathy.Mechanical and kinetic properties of β-cardiac/slow skeletal muscle myosin.Steric hindrance in the upper 50 kDa domain of the motor Myo2p leads to cytokinesis defects in fission yeast.Mechanical parameters of the molecular motor myosin II determined in permeabilised fibres from slow and fast skeletal muscles of the rabbit.Cross-bridges in slow skeletal muscle: not only slow but also soft.A Cardiomyopathy Mutation in the Myosin Essential Light Chain Alters Actomyosin Structure.Five Alternative Myosin Converter Domains Influence Muscle Power, Stretch Activation, and Kinetics.Do Actomyosin Single-Molecule Mechanics Data Predict Mechanics of Contracting Muscle?Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition
P2860
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P2860
Cardiomyopathy mutations reveal variable region of myosin converter as major element of cross-bridge compliance.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Cardiomyopathy mutations revea ...... nt of cross-bridge compliance.
@en
type
label
Cardiomyopathy mutations revea ...... nt of cross-bridge compliance.
@en
prefLabel
Cardiomyopathy mutations revea ...... nt of cross-bridge compliance.
@en
P2093
P2860
P1433
P1476
Cardiomyopathy mutations revea ...... ent of cross-bridge compliance
@en
P2093
A Francino
F Matinmehr
F Navarro-Lopéz
P2860
P304
P356
10.1016/J.BPJ.2009.05.023
P407
P577
2009-08-01T00:00:00Z