Functional consequences of mutations in the smooth muscle myosin heavy chain at sites implicated in familial hypertrophic cardiomyopathy.
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Understanding cardiomyopathy phenotypes based on the functional impact of mutations in the myosin motorThree-dimensional image reconstruction of dephosphorylated smooth muscle heavy meromyosin reveals asymmetry in the interaction between myosin heads and placement of subfragment 2Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function.The hypertrophic cardiomyopathy myosin mutation R453C alters ATP binding and hydrolysis of human cardiac β-myosinInsights into human beta-cardiac myosin function from single molecule and single cell studies.Myosin dynamics on the millisecond time scale.Sexually dimorphic myofilament function and cardiac troponin I phosphospecies distribution in hypertrophic cardiomyopathy miceThe R403Q myosin mutation implicated in familial hypertrophic cardiomyopathy causes disorder at the actomyosin interfaceMyosin individualized: single nucleotide polymorphisms in energy transduction.Myosin complexed with ADP and blebbistatin reversibly adopts a conformation resembling the start point of the working stroke.Biological, biochemical, and kinetic effects of mutations of the cardiomyopathy loop of Dictyostelium myosin II: importance of ALA400Mutation of the myosin converter domain alters cross-bridge elasticity.Suppression of muscle hypercontraction by mutations in the myosin heavy chain gene of Drosophila melanogaster.Mutations of the beta myosin heavy chain gene in hypertrophic cardiomyopathy: critical functional sites determine prognosis.A Failure to Communicate: MYOSIN RESIDUES INVOLVED IN HYPERTROPHIC CARDIOMYOPATHY AFFECT INTER-DOMAIN INTERACTION.Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backboneHead-head and head-tail interaction: a general mechanism for switching off myosin II activity in cellsSex dimorphisms of crossbridge cycling kinetics in transgenic hypertrophic cardiomyopathy miceHeterologous expression of wild-type and mutant beta-cardiac myosin changes the contractile kinetics of cultured mouse myotubes.A strain-dependency of Myosin off-rate must be sensitive to frequency to predict the B-process of sinusoidal analysis.Cardiomyopathy mutations reveal variable region of myosin converter as major element of cross-bridge compliance.Clinical Genetic Testing for the Cardiomyopathies and Arrhythmias: A Systematic Framework for Establishing Clinical Validity and Addressing Genotypic and Phenotypic Heterogeneity.Flexibility within the heads of muscle myosin-2 molecules.Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function.The myosin C-loop is an allosteric actin contact sensor in actomyosinThe two heads of smooth muscle myosin are enzymatically independent but mechanically interactive.The myosin cardiac loop participates functionally in the actomyosin interaction.Faster cross-bridge detachment and increased tension cost in human hypertrophic cardiomyopathy with the R403Q MYH7 mutation
P2860
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P2860
Functional consequences of mutations in the smooth muscle myosin heavy chain at sites implicated in familial hypertrophic cardiomyopathy.
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2000 nî lūn-bûn
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2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
@wuu
name
Functional consequences of mut ...... l hypertrophic cardiomyopathy.
@ast
Functional consequences of mut ...... l hypertrophic cardiomyopathy.
@en
type
label
Functional consequences of mut ...... l hypertrophic cardiomyopathy.
@ast
Functional consequences of mut ...... l hypertrophic cardiomyopathy.
@en
prefLabel
Functional consequences of mut ...... l hypertrophic cardiomyopathy.
@ast
Functional consequences of mut ...... l hypertrophic cardiomyopathy.
@en
P2093
P356
P1476
Functional consequences of mut ...... l hypertrophic cardiomyopathy.
@en
P2093
P304
28045-28052
P356
10.1074/JBC.M005485200
P407
P577
2000-09-01T00:00:00Z