Verapamil reversal of chloroquine resistance in the malaria parasite Plasmodium falciparum is specific for resistant parasites and independent of the weak base effect.
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The relationship of physico-chemical properties and structure to the differential antiplasmodial activity of the cinchona alkaloidsCharacterization of the commercially-available fluorescent chloroquine-BODIPY conjugate, LynxTag-CQGREEN, as a marker for chloroquine resistance and uptake in a 96-well plate assayMutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistanceExploiting large-scale drug-protein interaction information for computational drug repurposing.Mutations in pfmdr1 modulate the sensitivity of Plasmodium falciparum to the intrinsic antiplasmodial activity of verapamilMembrane transport in the malaria-infected erythrocyte.Chloroquine resistance in the malarial parasite, Plasmodium falciparum.Emerging targets for antimalarial drugs.Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistanceBlood Stage Plasmodium falciparum Exhibits Biological Responses to Direct Current Electric FieldsPlasmodium falciparum and Plasmodium vivax Demonstrate Contrasting Chloroquine Resistance Reversal Phenotypes.Molecular and physiologic basis of quinoline drug resistance in Plasmodium falciparum malariaRelationship between antimalarial drug activity, accumulation, and inhibition of heme polymerization in Plasmodium falciparum in vitro.In vitro increase in chloroquine accumulation induced by dihydroethano- and ethenoanthracene derivatives in Plasmodium falciparum-parasitized erythrocytesChloroquine susceptibility and reversibility in a Plasmodium falciparum genetic crossCellular uptake of chloroquine is dependent on binding to ferriprotoporphyrin IX and is independent of NHE activity in Plasmodium falciparumChloroquine transport in Plasmodium falciparum. 1. Influx and efflux kinetics for live trophozoite parasites using a novel fluorescent chloroquine probe.Analysis of the antimalarial drug resistance protein Pfcrt expressed in yeast.Does chloroquine really act through oxidative stress?Inhibition of the peroxidative degradation of haem as the basis of action of chloroquine and other quinoline antimalarialsNovel aryl-bis-quinolines with antimalarial activity in-vivo.Identification of a chloroquine importer in Plasmodium falciparum. Differences in import kinetics are genetically linked with the chloroquine-resistant phenotype.In vitro chemosensitization of Plasmodium falciparum to antimalarials by verapamil and probenecid.Identification of two distinct intracellular sites that contribute to the modulation of multidrug resistance in P388/ADR cells expressing P-glycoprotein.Chloroquine resistance--discovering the missing link?
P2860
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P2860
Verapamil reversal of chloroquine resistance in the malaria parasite Plasmodium falciparum is specific for resistant parasites and independent of the weak base effect.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Verapamil reversal of chloroqu ...... ndent of the weak base effect.
@en
type
label
Verapamil reversal of chloroqu ...... ndent of the weak base effect.
@en
prefLabel
Verapamil reversal of chloroqu ...... ndent of the weak base effect.
@en
P2093
P2860
P921
P356
P1476
Verapamil reversal of chloroqu ...... ndent of the weak base effect.
@en
P2093
P2860
P304
22393-22398
P356
10.1074/JBC.270.38.22393
P407
P577
1995-09-01T00:00:00Z