Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation
about
Targeted therapies in sarcomas: challenging the challengemiRNA-34c regulates Notch signaling during bone developmentNotch1 is a 5-fluorouracil resistant and poor survival marker in human esophagus squamous cell carcinomasGermline and somatic genetics of osteosarcoma - connecting aetiology, biology and therapy.γ-Secretase inhibitor enhances antitumour effect of radiation in Notch-expressing lung cancermicroRNA-139-5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancerSuppression of osteosarcoma cell invasion by chemotherapy is mediated by urokinase plasminogen activator activity via up-regulation of EGR1.Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells.The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptorEstablishment and characterization of a new highly metastatic human osteosarcoma cell line derived from Saos2.Targeting Notch1 signaling pathway positively affects the sensitivity of osteosarcoma to cisplatin by regulating the expression and/or activity of Caspase familyNotch activation as a driver of osteogenic sarcoma.RBPJ is a novel target for rhabdomyosarcoma therapy.Initial testing (stage 1) of the notch inhibitor PF-03084014, by the pediatric preclinical testing program.MicroRNA-221 induces cell survival and cisplatin resistance through PI3K/Akt pathway in human osteosarcoma.HES1, a target of Notch signaling, is elevated in canine osteosarcoma, but reduced in the most aggressive tumorsOsteosclerosis owing to Notch gain of function is solely Rbpj-dependentInhibition of the Notch-Hey1 axis blocks embryonal rhabdomyosarcoma tumorigenesis.Initial testing (stage 1) by the pediatric preclinical testing program of RO4929097, a γ-secretase inhibitor targeting notch signaling.Doxorubicin activates the Notch signaling pathway in osteosarcoma.Accumulation of p62 in degenerated spinal cord under chronic mechanical compression: functional analysis of p62 and autophagy in hypoxic neuronal cells.miR-181c associates with tumor relapse of high grade osteosarcomaHEY1 Leu94Met gene polymorphism dramatically modifies its biological functionsNotch Signaling and the Skeleton.Deciphering signaling networks in osteosarcoma pathobiology.Cisplatin selects for stem-like cells in osteosarcoma by activating Notch signaling.Inflammatory stress and sarcomagenesis: a vicious interplay.Tumour formation by single fibroblast growth factor receptor 3-positive rhabdomyosarcoma-initiating cellsNotch signaling in skeletal stem cells.MiR-34a-5p promotes multi-chemoresistance of osteosarcoma through down-regulation of the DLL1 gene.FOXC2 augments tumor propagation and metastasis in osteosarcoma.Molecular alterations as target for therapy in metastatic osteosarcoma: a review of literature.Therapeutic pipeline for soft-tissue sarcoma.Bone microenvironment signals in osteosarcoma development.Pericytes in sarcomas of bone.S-phase kinase-associated protein 2 promotes cell growth and motility in osteosarcoma cells.Modeling osteosarcoma progression by measuring the connectivity dynamics using an inference of multiple differential modules algorithm.MiR-26a inhibits stem cell-like phenotype and tumor growth of osteosarcoma by targeting Jagged1.Hairy/enhancer-of-split related with YRPW motif protein 1 promotes osteosarcoma metastasis via matrix metallopeptidase 9 expression.Overcoming Therapeutic Resistance of Bone Sarcomas: Overview of the Molecular Mechanisms and Therapeutic Targets for Bone Sarcoma Stem Cells.
P2860
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P2860
Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation
@en
type
label
Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation
@en
prefLabel
Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation
@en
P2093
P2860
P356
P1476
Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation
@en
P2093
T Setoguchi
Y Matsunoshita
P2860
P2888
P304
P356
10.1038/SJ.BJC.6605060
P407
P577
2009-05-19T00:00:00Z
P5875
P6179
1042287731