Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation - Wikidata - awgldk - TriplyDB

Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation

Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation

http://www.wikidata.org/entity/Q41935565

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Targeted therapies in sarcomas: challenging the challenge miRNA-34c regulates Notch signaling during bone development Notch1 is a 5-fluorouracil resistant and poor survival marker in human esophagus squamous cell carcinomas Germline and somatic genetics of osteosarcoma - connecting aetiology, biology and therapy.γ-Secretase inhibitor enhances antitumour effect of radiation in Notch-expressing lung cancer microRNA-139-5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancer Suppression of osteosarcoma cell invasion by chemotherapy is mediated by urokinase plasminogen activator activity via up-regulation of EGR1.Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells.The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptor Establishment and characterization of a new highly metastatic human osteosarcoma cell line derived from Saos2.Targeting Notch1 signaling pathway positively affects the sensitivity of osteosarcoma to cisplatin by regulating the expression and/or activity of Caspase family Notch activation as a driver of osteogenic sarcoma.RBPJ is a novel target for rhabdomyosarcoma therapy.Initial testing (stage 1) of the notch inhibitor PF-03084014, by the pediatric preclinical testing program.MicroRNA-221 induces cell survival and cisplatin resistance through PI3K/Akt pathway in human osteosarcoma.HES1, a target of Notch signaling, is elevated in canine osteosarcoma, but reduced in the most aggressive tumors Osteosclerosis owing to Notch gain of function is solely Rbpj-dependent Inhibition of the Notch-Hey1 axis blocks embryonal rhabdomyosarcoma tumorigenesis.Initial testing (stage 1) by the pediatric preclinical testing program of RO4929097, a γ-secretase inhibitor targeting notch signaling.Doxorubicin activates the Notch signaling pathway in osteosarcoma.Accumulation of p62 in degenerated spinal cord under chronic mechanical compression: functional analysis of p62 and autophagy in hypoxic neuronal cells.miR-181c associates with tumor relapse of high grade osteosarcoma HEY1 Leu94Met gene polymorphism dramatically modifies its biological functions Notch Signaling and the Skeleton.Deciphering signaling networks in osteosarcoma pathobiology.Cisplatin selects for stem-like cells in osteosarcoma by activating Notch signaling.Inflammatory stress and sarcomagenesis: a vicious interplay.Tumour formation by single fibroblast growth factor receptor 3-positive rhabdomyosarcoma-initiating cells Notch signaling in skeletal stem cells.MiR-34a-5p promotes multi-chemoresistance of osteosarcoma through down-regulation of the DLL1 gene.FOXC2 augments tumor propagation and metastasis in osteosarcoma.Molecular alterations as target for therapy in metastatic osteosarcoma: a review of literature.Therapeutic pipeline for soft-tissue sarcoma.Bone microenvironment signals in osteosarcoma development.Pericytes in sarcomas of bone.S-phase kinase-associated protein 2 promotes cell growth and motility in osteosarcoma cells.Modeling osteosarcoma progression by measuring the connectivity dynamics using an inference of multiple differential modules algorithm.MiR-26a inhibits stem cell-like phenotype and tumor growth of osteosarcoma by targeting Jagged1.Hairy/enhancer-of-split related with YRPW motif protein 1 promotes osteosarcoma metastasis via matrix metallopeptidase 9 expression.Overcoming Therapeutic Resistance of Bone Sarcomas: Overview of the Molecular Mechanisms and Therapeutic Targets for Bone Sarcoma Stem Cells.

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Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation

http://www.wikidata.org/entity/Q41935565

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2009年論文

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2009年论文

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2009年论文

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2009年论文

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name

Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation

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Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation

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Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation

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Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation

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H Gao

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H Sasaki

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M Hirotsu

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P2860

Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.

Mutations in the human Jagged1 gene are responsible for Alagille syndrome

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

Notch signaling: cell fate control and signal integration in development

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

Death and anti-death: tumour resistance to apoptosis

Signalling downstream of activated mammalian Notch

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

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