Localization of the K+ lock-In and the Ba2+ binding sites in a voltage-gated calcium-modulated channel. Implications for survival of K+ permeability
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Two mechanisms of ion selectivity in protein binding sitesA computational study of barium blockades in the KcsA potassium channel based on multi-ion potential of mean force calculations and free energy perturbation.Interchain hydrogen-bonding interactions may facilitate translocation of K+ ions across the potassium channel selectivity filter, as suggested by synthetic modeling chemistry.Regulation of a mammalian Shaker-related potassium channel, hKv1.5, by extracellular potassium and pH.The barium site in a potassium channel by x-ray crystallography.The conserved potassium channel filter can have distinct ion binding profiles: structural analysis of rubidium, cesium, and barium binding in NaK2KIon permeation and selectivity in ClC-type chloride channels.Potassium-selective block of barium permeation through single KcsA channelsMetal-driven operation of the human large-conductance voltage- and Ca2+-dependent potassium channel (BK) gating ring apparatus.External Ba2+ block of the two-pore domain potassium channel TREK-1 defines conformational transition in its selectivity filter.Evidence for a deep pore activation gate in small conductance Ca2+-activated K+ channels.KcsA: it's a potassium channelRegulation of K+ flow by a ring of negative charges in the outer pore of BKCa channels. Part II: Neutralization of aspartate 292 reduces long channel openings and gating current slow component.Regulation of K+ flow by a ring of negative charges in the outer pore of BKCa channels. Part I: Aspartate 292 modulates K+ conduction by external surface charge effectInteraction between quaternary ammonium ions in the pore of potassium channels. Evidence against an electrostatic repulsion mechanism.Affinity and location of an internal K+ ion binding site in shaker K channelsIon-Ion interactions at the selectivity filter. Evidence from K(+)-dependent modulation of tetraethylammonium efficacy in Kv2.1 potassium channels.Functional role and affinity of inorganic cations in stabilizing the tetrameric structure of the KcsA K+ channelInteraction of local anesthetics with the K (+) channel pore domain: KcsA as a model for drug-dependent tetramer stabilityClosed state-coupled C-type inactivation in BK channels.The relationship between duration of initial alcohol exposure and persistence of molecular tolerance is markedly nonlinear.Hydration number, topological control, and ion selectivity.Molecular Determinants of BK Channel Functional Diversity and Functioning.Quinidine interaction with Shab K+ channels: pore block and irreversible collapse of the K+ conductance.Stability of the Shab K+ channel conductance in 0 K+ solutions: the role of the membrane potential.Ion channel selectivity using an electric stew.Molecular motions in Fourier transform space.The pore helix dipole has a minor role in inward rectifier channel function.Mechanosensitivity of STREX-lacking BKCa channels in the colonic smooth muscle of the mouse.Residues lining the inner pore vestibule of human muscle chloride channels.Outer pore residues control the H(+) and K(+) sensitivity of the Arabidopsis potassium channel AKT3.Noradrenergic fiber sprouting and altered transduction in neuropathic prefrontal cortex.Regulation by external K+ in a maize inward shaker channel targets transport activity in the high concentration range.A K+ channel from salt-tolerant melon inhibited by Na+.Selectivity and interactions of Ba2+ and Cs+ with wild-type and mutant TASK1 K+ channels expressed in Xenopus oocytes.
P2860
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P2860
Localization of the K+ lock-In and the Ba2+ binding sites in a voltage-gated calcium-modulated channel. Implications for survival of K+ permeability
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Localization of the K+ lock-In ...... or survival of K+ permeability
@en
type
label
Localization of the K+ lock-In ...... or survival of K+ permeability
@en
prefLabel
Localization of the K+ lock-In ...... or survival of K+ permeability
@en
P2093
P2860
P356
P1476
Localization of the K+ lock-In ...... or survival of K+ permeability
@en
P2093
P2860
P304
P356
10.1085/JGP.114.3.365
P577
1999-09-01T00:00:00Z