Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy - Wikidata - awgldk - TriplyDB

Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy

Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy

http://www.wikidata.org/entity/Q41939336

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Metabolic Imaging to Assess Treatment Response to Cytotoxic and Cytostatic Agents Potential Clinical Roles for Metabolic Imaging with Hyperpolarized [1-(13)C]Pyruvate The use of dynamic nuclear polarization (13)C-pyruvate MRS in cancer Hyperpolarized magnetic resonance as a sensitive detector of metabolic function Chemistry and biochemistry of 13C hyperpolarized magnetic resonance using dynamic nuclear polarization HS-133, a novel fluorescent phosphatidylinositol 3-kinase inhibitor as a potential imaging and anticancer agent for targeted therapy Magnetic resonance spectroscopy detectable metabolomic fingerprint of response to antineoplastic treatment HDAC inhibition induces increased choline uptake and elevated phosphocholine levels in MCF7 breast cancer cells Model free approach to kinetic analysis of real-time hyperpolarized 13C magnetic resonance spectroscopy data Reduced Warburg effect in cancer cells undergoing autophagy: steady- state 1H-MRS and real-time hyperpolarized 13C-MRS studies Advanced magnetic resonance imaging of the physical processes in human glioblastoma.Single-shot single-voxel lactate measurements using FOCI-LASER and a multiple-quantum filter.Magnetic Resonance (MR) Metabolic Imaging in Glioma.Non-invasive metabolic imaging of brain tumours in the era of precision medicine.MR Molecular Imaging of Brain Cancer Metabolism Using Hyperpolarized 13C Magnetic Resonance Spectroscopy.Dichloroacetate induces autophagy in colorectal cancer cells and tumours.Metabolic imaging of patients with prostate cancer using hyperpolarized [1-¹³C]pyruvate On-target inhibition of tumor fermentative glycolysis as visualized by hyperpolarized pyruvate.Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research.A catalyzing phantom for reproducible dynamic conversion of hyperpolarized [1-¹³C]-pyruvate.17-allyamino-17-demethoxygeldanamycin treatment results in a magnetic resonance spectroscopy-detectable elevation in choline-containing metabolites associated with increased expression of choline transporter SLC44A1 and phospholipase A2 High-field small animal magnetic resonance oncology studies.Monitoring chemotherapeutic response by hyperpolarized 13C-fumarate MRS and diffusion MRI.Metabolic tumor imaging using magnetic resonance spectroscopy.Reduced phosphocholine and hyperpolarized lactate provide magnetic resonance biomarkers of PI3K/Akt/mTOR inhibition in glioblastoma.Probing lactate dehydrogenase activity in tumors by measuring hydrogen/deuterium exchange in hyperpolarized l-[1-(13)C,U-(2)H]lactate.Kinetic Modeling and Constrained Reconstruction of Hyperpolarized [1-13C]-Pyruvate Offers Improved Metabolic Imaging of Tumors.Comparison of kinetic models for analysis of pyruvate-to-lactate exchange by hyperpolarized 13 C NMR.Watching tumours gasp and die with MRI: the promise of hyperpolarised 13C MR spectroscopic imaging.Treatment with the MEK inhibitor U0126 induces decreased hyperpolarized pyruvate to lactate conversion in breast, but not prostate, cancer cells.Quantitative measurement of cancer metabolism using stimulated echo hyperpolarized carbon-13 MRS.MR Studies of Glioblastoma Models Treated with Dual PI3K/mTOR Inhibitor and Temozolomide:Metabolic Changes Are Associated with Enhanced Survival.Hyperpolarized (13)C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring.Human Hepatocellular Carcinoma Metabolism: Imaging by Hyperpolarized (13)C Magnetic Resonance Spectroscopy.Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13C-labeled glucose.Non-invasive in vivo assessment of IDH1 mutational status in glioma.Metabolic consequences of treatment with AKT inhibitor perifosine in breast cancer cells.GLUT3 upregulation promotes metabolic reprogramming associated with antiangiogenic therapy resistance.Current opportunities and challenges of magnetic resonance spectroscopy, positron emission tomography, and mass spectrometry imaging for mapping cancer metabolism in vivo.MR evaluation of response to targeted treatment in cancer cells.

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Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy

http://www.wikidata.org/entity/Q41939336

description

2010 nî lūn-bûn

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2010年の論文

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name

Noninvasive detection of targe ...... agnetic resonance spectroscopy

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Noninvasive detection of targe ...... agnetic resonance spectroscopy

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Noninvasive detection of targe ...... agnetic resonance spectroscopy

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0008-5472.CAN-09-2251

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Cancer Research

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Noninvasive detection of targe ...... agnetic resonance spectroscopy

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Alissa H Brandes

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C David James

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Christopher S Ward

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Daniel B Vigneron

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Daphne A Haas-Kogan

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Hagit Dafni

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Humsa S Venkatesh

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John Kurhanewicz

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Mark Vancriekinge

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Myriam M Chaumeil

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P2860

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1

Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR

Phosphoinositide 3-kinase signalling in breast cancer: how big a role might it play?

High frequency of mutations of the PIK3CA gene in human cancers

Why do cancers have high aerobic glycolysis?

Magnetic resonance detects changes in phosphocholine associated with Ras activation and inhibition in NIH 3T3 cells

Exploiting the PI3K/AKT pathway for cancer drug discovery

Tumor cell metabolism: cancer's Achilles' heel

Regulation of translation initiation by FRAP/mTOR

Java-based graphical user interface for MRUI, a software package for quantitation of in vivo/medical magnetic resonance spectroscopy signals.

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1296-1305

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20145128

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