The cytoplasmic domain of Alzheimer's amyloid precursor protein is phosphorylated at Thr654, Ser655, and Thr668 in adult rat brain and cultured cells.
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XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanismsProtein phosphatases and Alzheimer's diseasePin1 in Alzheimer's disease: multiple substrates, one regulatory mechanism?The amyloid-beta precursor protein is phosphorylated via distinct pathways during differentiation, mitosis, stress, and degeneration.Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP.Phosphorylation of amyloid precursor protein at threonine 668 is essential for its copper-responsive trafficking in SH-SY5Y neuroblastoma cells.The role of cell cycle-mediated events in Alzheimer's disease.The carboxy-terminal fragment of inhibitor-2 of protein phosphatase-2A induces Alzheimer disease pathology and cognitive impairment.Membrane-microdomain localization of amyloid β-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue.Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis.δ-COP modulates Aβ peptide formation via retrograde trafficking of APPRegulation of amyloid beta-protein precursor by phosphorylation and protein interactions.The interactome of the amyloid beta precursor protein family members is shaped by phosphorylation of their intracellular domains.Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model.An Aberrant Phosphorylation of Amyloid Precursor Protein Tyrosine Regulates Its Trafficking and the Binding to the Clathrin Endocytic Complex in Neural Stem Cells of Alzheimer's Disease Patients.Membrane rafts in Alzheimer's disease beta-amyloid production.Regulation of β cleavage of amyloid precursor proteinAlternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence.Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated.Modifications and Trafficking of APP in the Pathogenesis of Alzheimer's Disease.Enhanced generation of Alzheimer's amyloid-beta following chronic exposure to phorbol ester correlates with differential effects on alpha and epsilon isozymes of protein kinase C.X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain.cDNA isolation of Alzheimer's amyloid precursor protein from cholinergic nerve terminals of the electric organ of the electric ray.APP processing is regulated by cytoplasmic phosphorylation.GGA1 regulates signal-dependent sorting of BACE1 to recycling endosomes, which moderates Aβ production.
P2860
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P2860
The cytoplasmic domain of Alzheimer's amyloid precursor protein is phosphorylated at Thr654, Ser655, and Thr668 in adult rat brain and cultured cells.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
The cytoplasmic domain of Alzh ...... rat brain and cultured cells.
@en
type
label
The cytoplasmic domain of Alzh ...... rat brain and cultured cells.
@en
prefLabel
The cytoplasmic domain of Alzh ...... rat brain and cultured cells.
@en
P2093
P2860
P356
P1433
P1476
The cytoplasmic domain of Alzh ...... t rat brain and cultured cells
@en
P2093
P2860
P2888
P304
P356
10.1007/BF03401803
P407
P577
1997-02-01T00:00:00Z